clomipramine
A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
Ligand Summary
UNII: NUV44L116D
PubChem: 657299
PubChem: 2801
Guide to Pharmacology: 2398
ChEMBL: CHEMBL1200710
ChEMBL: CHEMBL415
DrugCentral: 701
LyCHI: SH6Q591YVBSV
Target Activities
SLC6A4
Sodium-dependent serotonin transporter
7 Activities
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1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 9.55 | |||||
Ki | 9.68 | |||||
Ki | 10.33 | None, None:None:None | ||||
IC50 | 10.06 | None, None:None:None | ||||
Ki | 9.55 | Bioorg. Med. Chem., (2015) 23:19:6528 | ||||
IC50 | 7.16 | J. Med. Chem., (1980) 23:12:1306 | ||||
Ki | 9.7 | INHIBITOR | ||||
SLC6A2
Sodium-dependent noradrenaline transporter
5 Activities
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1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 7.42 | |||||
IC50 | 7.19 | Bioorg. Med. Chem. Lett., (2013) 23:20:5515 | ||||
Ki | 7.16 | None, None:None:None | ||||
IC50 | 7.15 | None, None:None:None | ||||
Kd | 7.42 | INHIBITOR | ||||
CHRM4
Muscarinic acetylcholine receptor M4
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.89 | None, None:None:None | ||||
IC50 | 7.04 | None, None:None:None | ||||
HRH1
Histamine H1 receptor
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.01 | None, None:None:None | ||||
IC50 | 7.07 | None, None:None:None | ||||
CHRM1
Muscarinic acetylcholine receptor M1
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.66 | None, None:None:None | ||||
IC50 | 7.04 | None, None:None:None | ||||
ADRA2B
Alpha-2B adrenergic receptor
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.34 | None, None:None:None | ||||
IC50 | 7 | None, None:None:None | ||||
HTR2A
5-hydroxytryptamine receptor 2A
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.72 | None, None:None:None | ||||
IC50 | 7.17 | None, None:None:None | ||||
HTR2C
5-hydroxytryptamine receptor 2C
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.75 | None, None:None:None | ||||
IC50 | 7.47 | None, None:None:None | ||||
CHRM5
Muscarinic acetylcholine receptor M5
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.42 | None, None:None:None | ||||
IC50 | 7.28 | None, None:None:None | ||||
SLC6A3
Sodium-dependent dopamine transporter
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 5.66 | |||||
KCNJ6
G protein-activated inward rectifier potassium channel 2
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
4.4 | ||||||
KCNJ5
G protein-activated inward rectifier potassium channel 4
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
3.6 | ||||||
CHRM3
Muscarinic acetylcholine receptor M3
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.44 | None, None:None:None | ||||
DRD3
D(3) dopamine receptor
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.33 | None, None:None:None | ||||
SIGMAR1
Sigma non-opioid intracellular receptor 1
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 6.24 | None, None:None:None | ||||
ADRA1D
Alpha-1D adrenergic receptor
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.06 | None, None:None:None | ||||
CHRM2
Muscarinic acetylcholine receptor M2
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.07 | None, None:None:None | ||||