clomipramine
A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
Ligand Summary
UNII: NUV44L116D
PubChem: 2801
Guide to Pharmacology: 2398
ChEMBL: CHEMBL415
DrugCentral: 701
LyCHI: SH6Q591YVBSV
Target Activities
Items per page:
10
1 – 10 of 17
SLC6A4
Sodium-dependent serotonin transporter
6 Activities
Items per page:
1 – 6 of 6
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 9.55 | Bioorg. Med. Chem., (2015) 23:19:6528 | ||||
IC50 | 10.06 | None, None:None:None | ||||
Ki | 10.33 | None, None:None:None | ||||
Kd | 9.55000019 | |||||
Ki | 9.68000031 | |||||
Ki | 9.70335674 | INHIBITOR | ||||
SLC6A2
Sodium-dependent noradrenaline transporter
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.15 | None, None:None:None | ||||
Ki | 7.16 | None, None:None:None | ||||
IC50 | 7.19 | Bioorg. Med. Chem. Lett., (2013) 23:20:5515 | ||||
Kd | 7.42000008 | |||||
Kd | 7.4202 | INHIBITOR | ||||
HTR2C
5-hydroxytryptamine receptor 2C
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.47 | None, None:None:None | ||||
Ki | 7.75 | None, None:None:None | ||||
CHRM1
Muscarinic acetylcholine receptor M1
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.04 | None, None:None:None | ||||
Ki | 7.66 | None, None:None:None | ||||
CHRM4
Muscarinic acetylcholine receptor M4
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.04 | None, None:None:None | ||||
Ki | 7.89 | None, None:None:None | ||||
HTR2A
5-hydroxytryptamine receptor 2A
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.17 | None, None:None:None | ||||
Ki | 7.72 | None, None:None:None | ||||
HRH1
Histamine H1 receptor
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.07 | None, None:None:None | ||||
Ki | 8.01 | None, None:None:None | ||||
CHRM5
Muscarinic acetylcholine receptor M5
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.28 | None, None:None:None | ||||
Ki | 7.42 | None, None:None:None | ||||
ADRA2B
Alpha-2B adrenergic receptor
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7 | None, None:None:None | ||||
Ki | 7.34 | None, None:None:None | ||||
CHRM3
Muscarinic acetylcholine receptor M3
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.44 | None, None:None:None | ||||