ciclosporin
Ligand Summary
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
UNII: 83HN0GTJ6D
PubChem: 5284373
ChEMBL: CHEMBL160
DrugCentral: 760
LyCHI: MVAGBHGY6RMM
Target Activities
PPIA
Peptidyl-prolyl cis-trans isomerase A
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 8.05 | MODULATOR | ||||
ABCB11
Bile salt export pump
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 6.3 | |||||
FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 7.8 | |||||
PPIB
Peptidyl-prolyl cis-trans isomerase B
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Kd | 8.01 | |||||
PPP3CA
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Kd | 8.4 | |||||
FKBP1B
Peptidyl-prolyl cis-trans isomerase FKBP1B
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Ki | 8.22 | |||||
PPID
Peptidyl-prolyl cis-trans isomerase D
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Ki | 8.15 | |||||
SLCO1B1
Solute carrier organic anion transporter family member 1B1
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Ki | 7.29 | INHIBITOR | ||||
SLCO1B3
Solute carrier organic anion transporter family member 1B3
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 6.1 | INHIBITOR | ||||