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ceritinib

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
Ceritinib is a kinase inhibitor. Targets of ceritinib inhibition identified in either biochemical or cellular assays at clinically relevant concentrations include ALK, insulin-like growth factor 1 receptor (IGF-1R), insulin receptor (InsR), and ROS1. Among these, ceritinib is most active against ALK. Ceritinib inhibited autophosphorylation of ALK, ALK-mediated phosphorylation of the downstream signaling protein STAT3, and proliferation of ALK-dependent cancer cells in in vitro and in vivo assays.
Synonyms & Links
Guide to Pharmacology: 7397
DrugCentral: 4866
LyCHI:  BD9867SAV79T


Target Activities