Pharos : Ligand Details

Target Activities

PTGS2

Tclin

Prostaglandin G/H synthase 2

118 Activities

Items per page:

1 – 10 of 118

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6	J. Med. Chem., (1999) 42:7:1274	10197970

IC50	6	Bioorg. Med. Chem. Lett., (1999) 9:15:2207	10465547

IC50	6	Bioorg. Med. Chem. Lett., (1999) 9:22:3181	10576684

IC50	6	Bioorg. Med. Chem. Lett., (1999) 9:22:3187	10576685

IC50	6	Bioorg. Med. Chem. Lett., (2003) 13:6:1195	12643942

IC50	6	Bioorg. Med. Chem. Lett., (1999) 9:13:1773	10406640

IC50	6	Eur. J. Med. Chem., (2008) 43:6:1152	17976864

IC50	6.05	Bioorg. Med. Chem. Lett., (2015) 25:24:5787	26546221

IC50	6.06	Bioorg. Med. Chem., (2013) 21:8:2355	23473947

IC50	6.06	Bioorg. Med. Chem. Lett., (2016) 26:2:406	26691756

CA2

Tclin

Carbonic anhydrase 2

40 Activities

Items per page:

1 – 10 of 40

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.74	None, None:None:None

IC50	7.68	J. Med. Chem., (2004) 47:3:550	14736236

Ki	7.68	Bioorg. Med. Chem. Lett., (2005) 15:4:1149	15686931

Ki	7.68	J. Med. Chem., (2005) 48:18:5721	16134940

IC50	7.68	J. Med. Chem., (2005) 48:21:6523	16220969

Ki	7.68	Bioorg. Med. Chem. Lett., (2010) 20:15:4376	20605094

Ki	7.68	Bioorg. Med. Chem., (2010) 18:15:5498	20624682

Ki	7.68	J. Med. Chem., (2009) 52:9:3116	19338333

Ki	7.68	Bioorg. Med. Chem., (2009) 17:14:5054	19520577

Ki	7.68	Bioorg. Med. Chem. Lett., (2011) 21:19:5892	21852133

CA9

Tclin

Carbonic anhydrase 9

11 Activities

Items per page:

1 – 10 of 11

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.8	J. Med. Chem., (2004) 47:3:550	14736236

Ki	7.8	J. Med. Chem., (2005) 48:18:5721	16134940

IC50	7.8	J. Med. Chem., (2005) 48:21:6523	16220969

Ki	7.8	Bioorg. Med. Chem. Lett., (2010) 20:15:4376	20605094

Ki	7.8	Bioorg. Med. Chem. Lett., (2011) 21:19:5892	21852133

Ki	7.8	J. Med. Chem., (2012) 55:22:9619	23067387

Ki	7.8	Bioorg. Med. Chem., (2013) 21:19:5973	23965175

Ki	7.8	Bioorg. Med. Chem., (2014) 22:5:1586	24513184

Ki	7.8	Bioorg. Med. Chem., (2015) 23:8:1828	25766630

Ki	7.8	Bioorg. Med. Chem. Lett., (2006) 16:2:437	16290146

CA12

Tclin

Carbonic anhydrase 12

8 Activities

Items per page:

1 – 8 of 8

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.75	Bioorg. Med. Chem. Lett., (2010) 20:15:4376	20605094

Ki	7.75	Bioorg. Med. Chem. Lett., (2011) 21:19:5892	21852133

Ki	7.75	J. Med. Chem., (2012) 55:22:9619	23067387

Ki	7.75	Bioorg. Med. Chem., (2013) 21:19:5973	23965175

Ki	7.75	Bioorg. Med. Chem., (2014) 22:5:1586	24513184

Ki	7.75	Bioorg. Med. Chem., (2015) 23:8:1828	25766630

Ki	7.75	Bioorg. Med. Chem. Lett., (2006) 16:2:437	16290146

Ki	7.73999977		23965175

PTGS1

Tclin

Prostaglandin G/H synthase 1

6 Activities

Items per page:

1 – 6 of 6

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.14	None, None:None:None

IC50	7.3	J. Med. Chem., (1999) 42:7:1274	10197970

IC50	7.3	Bioorg. Med. Chem. Lett., (1999) 9:22:3181	10576684

IC50	7.3	Bioorg. Med. Chem. Lett., (1999) 9:22:3187	10576685

IC50	7.3	Bioorg. Med. Chem. Lett., (2003) 13:6:1195	12643942

IC50	4		29031075

PTGES

Tchem

Prostaglandin E synthase

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.27	J. Med. Chem., (2016) 59:1:194	26653180

IC50	6.27	Bioorg Med Chem Lett, (2016) 26:19:4824	27554445

IC50	6.37	J. Med. Chem., (2016) 59:1:194	26653180

CA6

Tclin

Carbonic anhydrase 6

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.03	Bioorg. Med. Chem. Lett., (2010) 20:15:4376	20605094

Ki	7.03	J. Med. Chem., (2012) 55:22:9619	23067387

Ki	7.03	J. Med. Chem., (2009) 52:3:646	19193158

CA4

Tclin

Carbonic anhydrase 4

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	6.06	Bioorg. Med. Chem. Lett., (2005) 15:4:1149	15686931

Ki	6.06	Bioorg. Med. Chem. Lett., (2010) 20:15:4376	20605094

Ki	6.06	J. Med. Chem., (2012) 55:22:9619	23067387

CA5B

Tclin

Carbonic anhydrase 5B, mitochondrial

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.03	Bioorg. Med. Chem. Lett., (2010) 20:15:4376	20605094

Ki	7.03	J. Med. Chem., (2012) 55:22:9619	23067387

CA13

Tclin

Carbonic anhydrase 13

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.01	Bioorg. Med. Chem. Lett., (2010) 20:15:4376	20605094

Ki	7.01	J. Med. Chem., (2012) 55:22:9619	23067387

CA14

Tclin

Carbonic anhydrase 14

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	6.16	Bioorg. Med. Chem. Lett., (2010) 20:15:4376	20605094

Ki	6.16	J. Med. Chem., (2012) 55:22:9619	23067387

CA5A

Tclin

Carbonic anhydrase 5A, mitochondrial

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	6.1	Bioorg. Med. Chem. Lett., (2010) 20:15:4376	20605094

Ki	6.1	J. Med. Chem., (2012) 55:22:9619	23067387

CYP2D6

Tclin

Cytochrome P450 2D6

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6		None, None:None:None