celecoxib
A pyrazole derivative and selective CYCLOOXYGENASE 2 INHIBITOR that is used to treat symptoms associated with RHEUMATOID ARTHRITIS; OSTEOARTHRITIS and JUVENILE ARTHRITIS, as well as the management of ACUTE PAIN.
Ligand Summary
UNII: JCX84Q7J1L
PubChem: 2662
Guide to Pharmacology: 2892
ChEMBL: CHEMBL118
DrugCentral: 568
LyCHI: DYM83CYSZL6G
Target Activities
Items per page:
10
1 – 10 of 13
PTGS2
Prostaglandin G/H synthase 2
118 Activities
Items per page:
1 – 10 of 118
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6 | J. Med. Chem., (1999) 42:7:1274 | ||||
IC50 | 6 | Bioorg. Med. Chem. Lett., (1999) 9:15:2207 | ||||
IC50 | 6 | Bioorg. Med. Chem. Lett., (1999) 9:22:3181 | ||||
IC50 | 6 | Bioorg. Med. Chem. Lett., (1999) 9:22:3187 | ||||
IC50 | 6 | Bioorg. Med. Chem. Lett., (2003) 13:6:1195 | ||||
IC50 | 6 | Bioorg. Med. Chem. Lett., (1999) 9:13:1773 | ||||
IC50 | 6 | Eur. J. Med. Chem., (2008) 43:6:1152 | ||||
IC50 | 6.05 | Bioorg. Med. Chem. Lett., (2015) 25:24:5787 | ||||
IC50 | 6.06 | Bioorg. Med. Chem., (2013) 21:8:2355 | ||||
IC50 | 6.06 | Bioorg. Med. Chem. Lett., (2016) 26:2:406 | ||||
CA2
Carbonic anhydrase 2
40 Activities
Items per page:
1 – 10 of 40
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.74 | None, None:None:None | ||||
IC50 | 7.68 | J. Med. Chem., (2004) 47:3:550 | ||||
Ki | 7.68 | Bioorg. Med. Chem. Lett., (2005) 15:4:1149 | ||||
Ki | 7.68 | J. Med. Chem., (2005) 48:18:5721 | ||||
IC50 | 7.68 | J. Med. Chem., (2005) 48:21:6523 | ||||
Ki | 7.68 | Bioorg. Med. Chem. Lett., (2010) 20:15:4376 | ||||
Ki | 7.68 | Bioorg. Med. Chem., (2010) 18:15:5498 | ||||
Ki | 7.68 | J. Med. Chem., (2009) 52:9:3116 | ||||
Ki | 7.68 | Bioorg. Med. Chem., (2009) 17:14:5054 | ||||
Ki | 7.68 | Bioorg. Med. Chem. Lett., (2011) 21:19:5892 | ||||
CA9
Carbonic anhydrase 9
11 Activities
Items per page:
1 – 10 of 11
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.8 | J. Med. Chem., (2004) 47:3:550 | ||||
Ki | 7.8 | J. Med. Chem., (2005) 48:18:5721 | ||||
IC50 | 7.8 | J. Med. Chem., (2005) 48:21:6523 | ||||
Ki | 7.8 | Bioorg. Med. Chem. Lett., (2010) 20:15:4376 | ||||
Ki | 7.8 | Bioorg. Med. Chem. Lett., (2011) 21:19:5892 | ||||
Ki | 7.8 | J. Med. Chem., (2012) 55:22:9619 | ||||
Ki | 7.8 | Bioorg. Med. Chem., (2013) 21:19:5973 | ||||
Ki | 7.8 | Bioorg. Med. Chem., (2014) 22:5:1586 | ||||
Ki | 7.8 | Bioorg. Med. Chem., (2015) 23:8:1828 | ||||
Ki | 7.8 | Bioorg. Med. Chem. Lett., (2006) 16:2:437 | ||||
CA12
Carbonic anhydrase 12
8 Activities
Items per page:
1 – 8 of 8
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.75 | Bioorg. Med. Chem. Lett., (2010) 20:15:4376 | ||||
Ki | 7.75 | Bioorg. Med. Chem. Lett., (2011) 21:19:5892 | ||||
Ki | 7.75 | J. Med. Chem., (2012) 55:22:9619 | ||||
Ki | 7.75 | Bioorg. Med. Chem., (2013) 21:19:5973 | ||||
Ki | 7.75 | Bioorg. Med. Chem., (2014) 22:5:1586 | ||||
Ki | 7.75 | Bioorg. Med. Chem., (2015) 23:8:1828 | ||||
Ki | 7.75 | Bioorg. Med. Chem. Lett., (2006) 16:2:437 | ||||
Ki | 7.73999977 | |||||
PTGS1
Prostaglandin G/H synthase 1
6 Activities
Items per page:
1 – 6 of 6
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.14 | None, None:None:None | ||||
IC50 | 7.3 | J. Med. Chem., (1999) 42:7:1274 | ||||
IC50 | 7.3 | Bioorg. Med. Chem. Lett., (1999) 9:22:3181 | ||||
IC50 | 7.3 | Bioorg. Med. Chem. Lett., (1999) 9:22:3187 | ||||
IC50 | 7.3 | Bioorg. Med. Chem. Lett., (2003) 13:6:1195 | ||||
IC50 | 4 | |||||