Pharos : Ligand Details

Target Activities

PTGS2

Tclin

Prostaglandin G/H synthase 2

158 Activities

Items per page:

1 – 10 of 158

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.52		29031075

IC50	8.7		12643942

IC50	9.28	Eur. J. Med. Chem., (2008) 43:6:1297	17714833

IC50	9.28	Eur. J. Med. Chem., (2008) 43:6:1297	17714833

IC50	8.7	J. Med. Chem., (1999) 42:7:1274	10197970

IC50	8.7	Bioorg. Med. Chem. Lett., (1999) 9:22:3181	10576684

IC50	8.7	Bioorg. Med. Chem. Lett., (1999) 9:22:3187	10576685

IC50	8.7	Bioorg. Med. Chem. Lett., (2003) 13:6:1195	12643942

IC50	8.66	Bioorg. Med. Chem. Lett., (2006) 16:17:4483	16806914

IC50	8.32	Bioorg Med Chem Lett, (2017) 27:11:2377	28427813

CA2

Tclin

Carbonic anhydrase 2

48 Activities

Items per page:

1 – 10 of 48

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.68	Bioorg. Med. Chem. Lett., (2004) 14:2:337	14698154

IC50	7.68	J. Med. Chem., (2004) 47:3:550	14736236

Ki	7.68	Bioorg. Med. Chem. Lett., (2005) 15:4:1149	15686931

Ki	7.68	J. Med. Chem., (2005) 48:18:5721	16134940

IC50	7.68	J. Med. Chem., (2005) 48:21:6523	16220969

Ki	7.68	Bioorg. Med. Chem. Lett., (2006) 16:2:437	16290146

Ki	7.68	J. Med. Chem., (2009) 52:9:3116	19338333

Ki	7.68	Bioorg. Med. Chem., (2009) 17:3:1158	19124253

Ki	7.68	J. Med. Chem., (2009) 52:3:646	19193158

Ki	7.68	J. Med. Chem., (2009) 52:8:2226	19317447

CA9

Tclin

Carbonic anhydrase 9

12 Activities

Items per page:

1 – 10 of 12

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.8	J. Med. Chem., (2004) 47:3:550	14736236

Ki	7.8	J. Med. Chem., (2005) 48:18:5721	16134940

IC50	7.8	J. Med. Chem., (2005) 48:21:6523	16220969

Ki	7.8	Bioorg. Med. Chem. Lett., (2006) 16:2:437	16290146

Ki	7.8	J. Med. Chem., (2009) 52:3:646	19193158

Ki	7.8	Bioorg. Med. Chem. Lett., (2010) 20:15:4376	20605094

Ki	7.8	Bioorg. Med. Chem. Lett., (2011) 21:19:5892	21852133

Ki	7.8	J. Med. Chem., (2012) 55:22:9619	23067387

Ki	7.8	Bioorg. Med. Chem., (2013) 21:19:5973	23965175

Ki	7.8	Bioorg. Med. Chem., (2014) 22:5:1586	24513184

PTGS1

Tclin

Prostaglandin G/H synthase 1

9 Activities

Items per page:

1 – 9 of 9

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	4		29031075

IC50	7.3	Bioorg. Med. Chem. Lett., (1999) 9:22:3181	10576684

IC50	7.3	Bioorg. Med. Chem. Lett., (1999) 9:22:3187	10576685

IC50	7.3	J. Med. Chem., (1999) 42:7:1274	10197970

IC50	7.3	Bioorg. Med. Chem. Lett., (2003) 13:6:1195	12643942

IC50	6.9	Bioorg Med Chem Lett, (2017) 27:11:2377	28427813

IC50	6.88	Eur J Med Chem, (2019) 171:None:332	30928706

IC50	6.52	Eur J Med Chem, (2019) 171:None:25	30904755

IC50	6.14	None, None:None:None

CA12

Tclin

Carbonic anhydrase 12

8 Activities

Items per page:

1 – 8 of 8

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.74		23965175

Ki	7.75	Bioorg. Med. Chem. Lett., (2006) 16:2:437	16290146

Ki	7.75	Bioorg. Med. Chem. Lett., (2010) 20:15:4376	20605094

Ki	7.75	Bioorg. Med. Chem. Lett., (2011) 21:19:5892	21852133

Ki	7.75	J. Med. Chem., (2012) 55:22:9619	23067387

Ki	7.75	Bioorg. Med. Chem., (2013) 21:19:5973	23965175

Ki	7.75	Bioorg. Med. Chem., (2014) 22:5:1586	24513184

Ki	7.75	Bioorg. Med. Chem., (2015) 23:8:1828	25766630

CA4

Tclin

Carbonic anhydrase 4

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	6.54	Bioorg Med Chem, (2017) 25:7:2210	28256371

Ki	6.06	Bioorg. Med. Chem. Lett., (2005) 15:4:1149	15686931

Ki	6.06	Bioorg. Med. Chem. Lett., (2010) 20:15:4376	20605094

Ki	6.06	J. Med. Chem., (2012) 55:22:9619	23067387

PTGES

Tchem

Prostaglandin E synthase

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.37	J. Med. Chem., (2016) 59:1:194	26653180

IC50	6.27	J. Med. Chem., (2016) 59:1:194	26653180

IC50	6.27	Bioorg Med Chem Lett, (2016) 26:19:4824	27554445

IC50	6.37	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL118

CA6

Tclin

Carbonic anhydrase 6

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.03	J. Med. Chem., (2009) 52:3:646	19193158

Ki	7.03	Bioorg. Med. Chem. Lett., (2010) 20:15:4376	20605094

Ki	7.03	J. Med. Chem., (2012) 55:22:9619	23067387

MT-CO2

Tchem

Cytochrome c oxidase subunit 2

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.53	Eur J Med Chem, (2019) 182:None:111601	31445233

IC50	6.27	Eur J Med Chem, (2017) 139:None:936	28881288

IC50	6.27	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL118

CA13

Tclin

Carbonic anhydrase 13

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.01	Bioorg. Med. Chem. Lett., (2010) 20:15:4376	20605094

Ki	7.01	J. Med. Chem., (2012) 55:22:9619	23067387

CA14

Tclin

Carbonic anhydrase 14

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	6.16	Bioorg. Med. Chem. Lett., (2010) 20:15:4376	20605094

Ki	6.16	J. Med. Chem., (2012) 55:22:9619	23067387

CA5B

Tclin

Carbonic anhydrase 5B, mitochondrial

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.03	Bioorg. Med. Chem. Lett., (2010) 20:15:4376	20605094

Ki	7.03	J. Med. Chem., (2012) 55:22:9619	23067387

CA5A

Tclin

Carbonic anhydrase 5A, mitochondrial

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	6.1	Bioorg. Med. Chem. Lett., (2010) 20:15:4376	20605094

Ki	6.1	J. Med. Chem., (2012) 55:22:9619	23067387

HDAC6

Tclin

Histone deacetylase 6

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.19		Bioorg Med Chem, (2018) 26:8:1418	29500130

CYP2D6

Tclin

Cytochrome P450 2D6

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6		None, None:None:None