celecoxib
Ligand Summary
A pyrazole derivative and selective CYCLOOXYGENASE 2 INHIBITOR that is used to treat symptoms associated with RHEUMATOID ARTHRITIS; OSTEOARTHRITIS and JUVENILE ARTHRITIS, as well as the management of ACUTE PAIN.
UNII: JCX84Q7J1L
PubChem: 2662
Guide to Pharmacology: 2892
ChEMBL: CHEMBL118
DrugCentral: 568
LyCHI: DYM83CYSZL6G
Target Activities
PTGS2
Prostaglandin G/H synthase 2
158 Activities
Items per page:
1 – 10 of 158
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 6.52 | |||||
IC50 | 8.7 | |||||
IC50 | 9.28 | Eur. J. Med. Chem., (2008) 43:6:1297 | ||||
IC50 | 9.28 | Eur. J. Med. Chem., (2008) 43:6:1297 | ||||
IC50 | 8.7 | J. Med. Chem., (1999) 42:7:1274 | ||||
IC50 | 8.7 | Bioorg. Med. Chem. Lett., (1999) 9:22:3181 | ||||
IC50 | 8.7 | Bioorg. Med. Chem. Lett., (1999) 9:22:3187 | ||||
IC50 | 8.7 | Bioorg. Med. Chem. Lett., (2003) 13:6:1195 | ||||
IC50 | 8.66 | Bioorg. Med. Chem. Lett., (2006) 16:17:4483 | ||||
IC50 | 8.32 | Bioorg Med Chem Lett, (2017) 27:11:2377 | ||||
CA2
Carbonic anhydrase 2
48 Activities
Items per page:
1 – 10 of 48
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.68 | Bioorg. Med. Chem. Lett., (2004) 14:2:337 | ||||
IC50 | 7.68 | J. Med. Chem., (2004) 47:3:550 | ||||
Ki | 7.68 | Bioorg. Med. Chem. Lett., (2005) 15:4:1149 | ||||
Ki | 7.68 | J. Med. Chem., (2005) 48:18:5721 | ||||
IC50 | 7.68 | J. Med. Chem., (2005) 48:21:6523 | ||||
Ki | 7.68 | Bioorg. Med. Chem. Lett., (2006) 16:2:437 | ||||
Ki | 7.68 | J. Med. Chem., (2009) 52:9:3116 | ||||
Ki | 7.68 | Bioorg. Med. Chem., (2009) 17:3:1158 | ||||
Ki | 7.68 | J. Med. Chem., (2009) 52:3:646 | ||||
Ki | 7.68 | J. Med. Chem., (2009) 52:8:2226 | ||||
CA9
Carbonic anhydrase 9
12 Activities
Items per page:
1 – 10 of 12
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.8 | J. Med. Chem., (2004) 47:3:550 | ||||
Ki | 7.8 | J. Med. Chem., (2005) 48:18:5721 | ||||
IC50 | 7.8 | J. Med. Chem., (2005) 48:21:6523 | ||||
Ki | 7.8 | Bioorg. Med. Chem. Lett., (2006) 16:2:437 | ||||
Ki | 7.8 | J. Med. Chem., (2009) 52:3:646 | ||||
Ki | 7.8 | Bioorg. Med. Chem. Lett., (2010) 20:15:4376 | ||||
Ki | 7.8 | Bioorg. Med. Chem. Lett., (2011) 21:19:5892 | ||||
Ki | 7.8 | J. Med. Chem., (2012) 55:22:9619 | ||||
Ki | 7.8 | Bioorg. Med. Chem., (2013) 21:19:5973 | ||||
Ki | 7.8 | Bioorg. Med. Chem., (2014) 22:5:1586 | ||||
PTGS1
Prostaglandin G/H synthase 1
9 Activities
Items per page:
1 – 9 of 9
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 4 | |||||
IC50 | 7.3 | Bioorg. Med. Chem. Lett., (1999) 9:22:3181 | ||||
IC50 | 7.3 | Bioorg. Med. Chem. Lett., (1999) 9:22:3187 | ||||
IC50 | 7.3 | J. Med. Chem., (1999) 42:7:1274 | ||||
IC50 | 7.3 | Bioorg. Med. Chem. Lett., (2003) 13:6:1195 | ||||
IC50 | 6.9 | Bioorg Med Chem Lett, (2017) 27:11:2377 | ||||
IC50 | 6.88 | Eur J Med Chem, (2019) 171:None:332 | ||||
IC50 | 6.52 | Eur J Med Chem, (2019) 171:None:25 | ||||
IC50 | 6.14 | None, None:None:None | ||||
CA12
Carbonic anhydrase 12
8 Activities
Items per page:
1 – 8 of 8
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.74 | |||||
Ki | 7.75 | Bioorg. Med. Chem. Lett., (2006) 16:2:437 | ||||
Ki | 7.75 | Bioorg. Med. Chem. Lett., (2010) 20:15:4376 | ||||
Ki | 7.75 | Bioorg. Med. Chem. Lett., (2011) 21:19:5892 | ||||
Ki | 7.75 | J. Med. Chem., (2012) 55:22:9619 | ||||
Ki | 7.75 | Bioorg. Med. Chem., (2013) 21:19:5973 | ||||
Ki | 7.75 | Bioorg. Med. Chem., (2014) 22:5:1586 | ||||
Ki | 7.75 | Bioorg. Med. Chem., (2015) 23:8:1828 | ||||
CA4
Carbonic anhydrase 4
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 6.54 | Bioorg Med Chem, (2017) 25:7:2210 | ||||
Ki | 6.06 | Bioorg. Med. Chem. Lett., (2005) 15:4:1149 | ||||
Ki | 6.06 | Bioorg. Med. Chem. Lett., (2010) 20:15:4376 | ||||
Ki | 6.06 | J. Med. Chem., (2012) 55:22:9619 | ||||
PTGES
Prostaglandin E synthase
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 6.37 | J. Med. Chem., (2016) 59:1:194 | ||||
IC50 | 6.27 | J. Med. Chem., (2016) 59:1:194 | ||||
IC50 | 6.27 | Bioorg Med Chem Lett, (2016) 26:19:4824 | ||||
IC50 | 6.37 | |||||
CA6
Carbonic anhydrase 6
3 Activities
MT-CO2
Cytochrome c oxidase subunit 2
3 Activities
Items per page:
1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 6.53 | Eur J Med Chem, (2019) 182:None:111601 | ||||
IC50 | 6.27 | Eur J Med Chem, (2017) 139:None:936 | ||||
IC50 | 6.27 | |||||
CA13
Carbonic anhydrase 13
2 Activities
CA14
Carbonic anhydrase 14
2 Activities
CA5B
Carbonic anhydrase 5B, mitochondrial
2 Activities
CA5A
Carbonic anhydrase 5A, mitochondrial
2 Activities
HDAC6
Histone deacetylase 6
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 6.19 | Bioorg Med Chem, (2018) 26:8:1418 | ||||
CYP2D6
Cytochrome P450 2D6
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 6 | None, None:None:None | ||||