captopril
A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.
Ligand Summary
UNII: 9G64RSX1XD
PubChem: 44093
Guide to Pharmacology: 5158
ChEMBL: CHEMBL1560
DrugCentral: 484
LyCHI: DCTASLNAXK1N
Target Activities
ACE
Angiotensin-converting enzyme
30 Activities
Items per page:
1 – 10 of 30
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.4 | |||||
IC50 | 9.92 | Bioorg. Med. Chem. Lett., (2009) 19:16:4715 | ||||
IC50 | 9.2 | J. Med. Chem., (2008) 51:14:4150 | ||||
IC50 | 8.79 | J. Nat. Prod., (2015) 78:5:1179 | ||||
Ki | 8.7 | J. Med. Chem., (2013) 56:21:8377 | ||||
IC50 | 8.3 | J. Nat. Prod., (1988) 51:2:357 | ||||
IC50 | 8.2 | J Med Chem, (2018) 61:9:3779 | ||||
IC50 | 8.05 | J. Med. Chem., (1981) 24:8:964 | ||||
IC50 | 8 | Bioorg. Med. Chem. Lett., (1994) 4:22:2715 | ||||
IC50 | 7.96 | Eur. J. Med. Chem., (2014) 79:None:184 | ||||
LTA4H
Leukotriene A-4 hydrolase
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.16 | Bioorg. Med. Chem. Lett., (1991) 1:10:551 | ||||
IC50 | 7.15 | |||||
F2
Prothrombin
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.32 | Bioorg. Med. Chem. Lett., (2004) 14:14:3727 | ||||
REN
Renin
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.77 | J. Med. Chem., (1981) 24:4:355 | ||||