captopril
A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.
Ligand Summary
UNII: 9G64RSX1XD
PubChem: 44093
Guide to Pharmacology: 5158
ChEMBL: CHEMBL1560
DrugCentral: 484
LyCHI: DCTASLNAXK1N
Target Activities
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10
1 – 4 of 4
ACE
Angiotensin-converting enzyme
22 Activities
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1 – 10 of 22
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.52 | J. Med. Chem., (1985) 28:8:1062 | ||||
IC50 | 6.52 | J. Med. Chem., (1980) 23:12:1392 | ||||
IC50 | 7.1 | J. Med. Chem., (1997) 40:20:3161 | ||||
IC50 | 7.52 | Bioorg. Med. Chem. Lett., (1993) 3:10:1953 | ||||
IC50 | 7.64 | MedChemComm, (2012) 3:10:1290 | ||||
IC50 | 7.64 | J. Med. Chem., (2005) 48:21:6523 | ||||
IC50 | 7.64 | Bioorg. Med. Chem. Lett., (2008) 18:16:4529 | ||||
IC50 | 7.64 | J. Med. Chem., (2000) 43:3:305 | ||||
IC50 | 7.68 | J. Med. Chem., (2013) 56:20:7997 | ||||
IC50 | 7.7 | J. Med. Chem., (1985) 28:4:434 | ||||
LTA4H
Leukotriene A-4 hydrolase
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.16 | Bioorg. Med. Chem. Lett., (1991) 1:10:551 | ||||
IC50 | 7.15 | |||||
REN
Renin
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.77 | J. Med. Chem., (1981) 24:4:355 | ||||
F2
Prothrombin
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.32 | Bioorg. Med. Chem. Lett., (2004) 14:14:3727 | ||||