Pharos : Ligand Details

Target Activities

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1 – 9 of 9

RET

Tclin

Proto-oncogene tyrosine-protein kinase receptor Ret

11 Activities

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1 – 10 of 11

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.75	J. Med. Chem., (2016) 59:1:358	26652860

IC50	7.8	Bioorg. Med. Chem. Lett., (2014) 24:15:3351	24951334

IC50	7.85	J. Med. Chem., (2016) 59:1:358	26652860

IC50	8.15	J. Med. Chem., (2016) 59:1:358	26652860

IC50	8.28	Eur. J. Med. Chem., (2016) 108:None:495	26717201

IC50	8.3	J. Med. Chem., (2016) 59:1:358	26652860

IC50	8.3	J. Med. Chem., (2015) 58:9:3672	25625428

IC50	8.4	J Med Chem, (2016) 59:19:8712	27299736

IC50	8.52	Eur. J. Med. Chem., (2016) 118:None:244	27131066

IC50	7.96000004		29657135

KDR

Tclin

Vascular endothelial growth factor receptor 2

10 Activities

Items per page:

1 – 10 of 10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.8		Eur. J. Med. Chem., (2016) 112:None:20	26874741

IC50	7.85		Eur. J. Med. Chem., (2016) 112:None:20	26874741

IC50	8.15		Bioorg. Med. Chem. Lett., (2014) 24:15:3351	24951334

IC50	8.15		Eur. J. Med. Chem., (2014) 83:None:581	24996144

IC50	8.52		Bioorg. Med. Chem., (2016) 24:16:3353	27068889

IC50	10.46		Eur. J. Med. Chem., (2016) 108:None:495	26717201

IC50	10.46		Bioorg. Med. Chem., (2016) 24:16:3353	27068889

IC50	10.46		J Med Chem, (2016) 59:19:8712	27299736

IC50	10.46000004			21926191

IC50	10.45593166	INHIBITOR	http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/203756lbl.pdf

MET

Tclin

Hepatocyte growth factor receptor

9 Activities

Items per page:

1 – 9 of 9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.68		Eur. J. Med. Chem., (2014) 83:None:581	24996144

IC50	8.1		Bioorg. Med. Chem. Lett., (2014) 24:15:3351	24951334

IC50	8.43		Bioorg. Med. Chem., (2015) 23:3:564	25537530

IC50	8.49		Bioorg. Med. Chem., (2016) 24:16:3353	27068889

IC50	8.89		Eur. J. Med. Chem., (2016) 108:None:495	26717201

IC50	8.89		Bioorg. Med. Chem., (2016) 24:16:3353	27068889

IC50	8.89		J Med Chem, (2016) 59:19:8712	27299736

IC50	8.89999962			21926191

IC50	8.8860569	INHIBITOR	http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/203756lbl.pdf

KIT

Tclin

Mast/stem cell growth factor receptor Kit

4 Activities

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1 – 4 of 4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.34		Eur. J. Med. Chem., (2016) 108:None:495	26717201

IC50	8.34		J Med Chem, (2016) 59:19:8712	27299736

IC50	8.4		Bioorg. Med. Chem. Lett., (2014) 24:15:3351	24951334

IC50	8.33724213	INHIBITOR	http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/203756lbl.pdf

TEK

Tclin

Angiopoietin-1 receptor

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.84		Eur. J. Med. Chem., (2016) 108:None:495	26717201

IC50	7.84		J Med Chem, (2016) 59:19:8712	27299736

IC50	7.8446641	INHIBITOR	http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/203756lbl.pdf

FLT3

Tclin

Receptor-type tyrosine-protein kinase FLT3

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.95		Eur. J. Med. Chem., (2016) 108:None:495	26717201

IC50	8.22		J Med Chem, (2016) 59:19:8712	27299736

IC50	7.94692135	INHIBITOR	http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/203756lbl.pdf

AXL

Tchem

Tyrosine-protein kinase receptor UFO

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.15	Eur. J. Med. Chem., (2016) 108:None:495	26717201

IC50	8.15	J Med Chem, (2016) 59:19:8712	27299736

FGFR1

Tclin

Fibroblast growth factor receptor 1

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.95		J Med Chem, (2016) 59:19:8712	27299736

FLT1

Tclin

Vascular endothelial growth factor receptor 1

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.92		J Med Chem, (2016) 59:19:8712	27299736