buprenorphine
Ligand Summary
A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use.
UNII: 40D3SCR4GZ
PubChem: 644073
Guide to Pharmacology: 1670
ChEMBL: CHEMBL560511
DrugCentral: 434
LyCHI: 1MYL2TZ39DL2
Target Activities
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Ki | ||||||
Ki | PARTIAL AGONIST | |||||
Ki | ANTAGONIST | |||||
Ki | ||||||