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buprenorphine

Ligand Summary
Ligand Structure
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Description
A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use.
Synonyms & Links
Guide to Pharmacology: 1670
DrugCentral: 434
LyCHI:  1MYL2TZ39DL2


Target Activities