Pharos : Ligand Details - brigatinib

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Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

Name: brigatinib

PubChem: 57390074

Guide to Pharmacology: 7741

ChEMBL: CHEMBL3397300

LyCHI: NSL4GK65GM2W

Target Activities

ALK

Tclin

ALK tyrosine kinase receptor

3 Activities

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1 – 3 of 3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	10.05			21502504

IC50	10.15		J. Med. Chem., (2016) 59:10:4948	27144831

IC50	9.21		Eur. J. Med. Chem., (2015) 90:None:195	25461320

IGF1R

Tclin

Insulin-like growth factor 1 receptor

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.61			27144831

IC50	8.49		J. Med. Chem., (2016) 59:10:4948	27144831

EGFR

Tclin

Epidermal growth factor receptor

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.89			21502504

INSR

Tclin

Insulin receptor

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.71			27144831

ROS1

Tclin

Proto-oncogene tyrosine-protein kinase ROS

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.72		Eur. J. Med. Chem., (2015) 90:None:195	25461320