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botulinum toxin type A

Ligand Summary
Description
Botulinum toxin type A (Clostridium botulinum neurotoxin) blocks peripheral acetylcholine release at presynaptic cholinergic nerve terminals by cleaving SNAP-25, a protein integral to the successful docking and release of acetylcholine from vesicles situated within the nerve endings, thereby leading to denervation of the muscle and a flaccid paralysis.
Synonyms & Links
DrugCentral: 5368
LyCHI:  botulinum toxin type A