boceprevir
Ligand Summary
Boceprevir is an inhibitor of the HCV NS3/4A protease that is necessary for the proteolytic cleavage of the HCV encoded polyprotein into mature forms of the NS4A, NS4B, NS5A and NS5B proteins. Boceprevir covalently, yet reversibly, binds to the NS3 protease active site serine (S139) through an (alpha)-ketoamide functional group to inhibit viral replication in HCV-infected host cells. In a biochemical assay, boceprevir inhibited the activity of recombinant HCV genotype 1a and 1b NS3/4A protease enzymes, with Ki values of 14 nM for each subtype.
UNII: 89BT58KELH
PubChem: 10324367
Guide to Pharmacology: 7876
ChEMBL: CHEMBL218394
DrugCentral: 4172
LyCHI: FC2DSF1KRQ5F
Target Activities
11 Activities
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