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binimetinib

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
Binimetinib is a reversible inhibitor of mitogen-activated extracellular signal regulated kinase 1 (MEK1) and MEK2 activity. MEK proteins are upstream regulators of the extracellular signal-related kinase (ERK) pathway. In vitro, binimetinib inhibited extracellular signal-related kinase (ERK) phosphorylation in cellfree assays as well as viability and MEK-dependent phosphorylation of BRAF-mutant human melanoma cell lines. Binimetinib also inhibited in vivo ERK phosphorylation and tumor growth in BRAF-mutant murine xenograft models.
Synonyms & Links
Guide to Pharmacology: 7921
DrugCentral: 5290
LyCHI:  T5F4WDQXB4V3


Target Activities