bepridil
A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.
Ligand Summary
UNII: 755BO701MA
PubChem: 2351
Guide to Pharmacology: 2337
ChEMBL: CHEMBL1008
DrugCentral: 342
LyCHI: S1UMSUMGTCRA
Target Activities
KCNH2
Potassium voltage-gated channel subfamily H member 2
13 Activities
Items per page:
1 – 10 of 13
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.64 | Eur. J. Med. Chem., (2011) 46:2:618 | ||||
IC50 | 7.48 | Cardiovasc. Res., (2011) 91:None:53 | ||||
Ki | 6.74 | J. Med. Chem., (2007) 50:13:2931 | ||||
Ki | 6.54 | J. Med. Chem., (2007) 50:13:2931 | ||||
IC50 | 6.37 | Bioorg. Med. Chem. Lett., (2004) 14:18:4771 | ||||
Ki | 6.35 | Bioorg. Med. Chem. Lett., (2006) 16:20:5303 | ||||
IC50 | 6.26 | J. Med. Chem., (2002) 45:18:3844 | ||||
IC50 | 6.26 | Bioorg. Med. Chem. Lett., (2003) 13:16:2773 | ||||
IC50 | 6.26 | Bioorg. Med. Chem. Lett., (2005) 15:11:2886 | ||||
IC50 | 6.26 | Bioorg. Med. Chem. Lett., (2005) 15:6:1737 | ||||
CACNA1C
Voltage-dependent L-type calcium channel subunit alpha-1C
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 5.85 | Journal of Applied Toxicology, (2012) 32:None:858 | ||||
BLOCKER | ||||||
KCNQ4
Potassium voltage-gated channel subfamily KQT member 4
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
5 | ||||||
SCN5A
Sodium channel protein type 5 subunit alpha
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 5.43 | Cardiovasc. Res., (2011) 91:None:53 | ||||
CACNA1H
Voltage-dependent T-type calcium channel subunit alpha-1H
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 5.15 | BLOCKER | ||||
CACNA1D
Voltage-dependent L-type calcium channel subunit alpha-1D
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
BLOCKER | ||||||