Pharos : Ligand Details - benzbromarone

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Uricosuric that acts by increasing uric acid clearance. It is used in the treatment of gout.

Ligand Summary

Ligand Structure

chemical structure image

Synonyms & Links

UNII: 4POG0RL69O

PubChem: 2333

ChEMBL: CHEMBL388590

DrugCentral: 318

LyCHI: L1B5DR6HXMQL

Target Activities

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10

1 – 4 of 4

SLC22A12

Tclin

Solute carrier family 22 member 12

7 Activities

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1 – 7 of 7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.12		None, (2014) None:None:None

IC50	6.12		None, (2014) None:None:None

IC50	6.52		Drug Metab. Dispos., (2007) 35:6:981	17325024

IC50	7.46		J. Med. Chem., (2011) 54:8:2701	21449597

IC50	7.58		J. Med. Chem., (2011) 54:8:2701	21449597

IC50	7.66		MedChemComm, (2016) 7:8:1587

IC50	7.59	INHIBITOR	http://www.ncbi.nlm.nih.gov/pubmed/16135657

AKR1C1

Tchem

Aldo-keto reductase family 1 member C1

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.32		J. Med. Chem., (2009) 52:10:3259	19397269

IC50	7.32		https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL388590

ABCC1

Tchem

Multidrug resistance-associated protein 1

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	6.72		Bioorg. Med. Chem., (2011) 19:10:3249	21530277

Ki	6.72		https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL388590

CYP2C9

Tchem

Cytochrome P450 2C9

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.8		None, None:None:None