Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

SLC6A3

Tclin

Sodium-dependent dopamine transporter

5 Activities

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1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	6.93		7562926

Ki	6.71	None, None:None:None

IC50	6.61	None, None:None:None

IC50	6.51	J. Med. Chem., (1994) 37:13:2001	8027983

IC50	6.51	J. Med. Chem., (1996) 39:2:371	8558504

CHRM1

Tclin

Muscarinic acetylcholine receptor M1

4 Activities

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1 – 4 of 4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	9.02			7562926

Ki	9.88		None, None:None:None

IC50	9.26		None, None:None:None

Ki	9.64	ANTAGONIST	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1201203

CHRM2

Tclin

Muscarinic acetylcholine receptor M2

3 Activities

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1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	8.59		7562926

Ki	8.44	None, None:None:None

IC50	8	None, None:None:None

CHRM3

Tclin

Muscarinic acetylcholine receptor M3

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	9.56	None, None:None:None

IC50	8.89	None, None:None:None

CHRM4

Tclin

Muscarinic acetylcholine receptor M4

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	9.48	None, None:None:None

IC50	8.62	None, None:None:None

HRH1

Tclin

Histamine H1 receptor

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	9.43	None, None:None:None

IC50	8.5	None, None:None:None

SIGMAR1

Tclin

Sigma non-opioid intracellular receptor 1

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	7.23	None, None:None:None

IC50	6.86	None, None:None:None

ADRA1D

Tclin

Alpha-1D adrenergic receptor

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	7.58	None, None:None:None

IC50	7.28	None, None:None:None

ADRA2B

Tclin

Alpha-2B adrenergic receptor

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	7.52	None, None:None:None

IC50	7.19	None, None:None:None

HTR2A

Tclin

5-hydroxytryptamine receptor 2A

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	8.16	None, None:None:None

IC50	7.62	None, None:None:None

HTR2C

Tclin

5-hydroxytryptamine receptor 2C

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	7.5	None, None:None:None

IC50	7.21	None, None:None:None

CHRM5

Tclin

Muscarinic acetylcholine receptor M5

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	8.84	None, None:None:None

IC50	8.7	None, None:None:None

SLC6A19

Tchem

Sodium-dependent neutral amino acid transporter B(0)AT1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	4.36			28176326

ADRA2C

Tclin

Alpha-2C adrenergic receptor

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.24		None, None:None:None