baclofen
Ligand Summary
A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPASTICITY, especially that due to SPINAL CORD INJURIES. Its therapeutic effects result from actions at spinal and supraspinal sites, generally the reduction of excitatory transmission.
UNII: H789N3FKE8
PubChem: 2284
ChEMBL: CHEMBL701
DrugCentral: 282
LyCHI: USJMSKZ6V3XF
Target Activities
GABBR2
Gamma-aminobutyric acid type B receptor subunit 2
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.46 | AGONIST | ||||
GABBR1
Gamma-aminobutyric acid type B receptor subunit 1
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.46 | AGONIST | ||||
ADORA3
Adenosine receptor A3
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.3 | |||||