axitinib
A benzamide and indazole derivative that acts as a TYROSINE KINASE inhibitor of the VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR. It is used in the treatment of advanced RENAL CELL CARCINOMA.
Ligand Summary
UNII: C9LVQ0YUXG
PubChem: 6450551
Guide to Pharmacology: 5659
ChEMBL: CHEMBL1289926
DrugCentral: 4225
LyCHI: C9S74HT6XVFD
Target Activities
ABL1
Tyrosine-protein kinase ABL1
8 Activities
Items per page:
1 – 8 of 8
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 7.64 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.7 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IC50 | 8.11 | None, (2015) None:None:None | ||||
Kd | 8.44 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IC50 | 8.59 | None, (2015) None:None:None | ||||
Kd | 8.82 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IC50 | 9.26 | None, (2015) None:None:None | ||||
IC50 | 9.38 | None, (2015) None:None:None | ||||
KDR
Vascular endothelial growth factor receptor 2
7 Activities
Items per page:
1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 8.23 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Ki | 8.42 | |||||
Ki | 8.42 | None, (2003) None:None:None | ||||
IC50 | 9.6 | Eur. J. Med. Chem., (2010) 45:11:5420 | ||||
IC50 | 9.60000038 | |||||
Kd | 8.22999954 | |||||
Kd | 8.23 | INHIBITOR | ||||
PLK4
Serine/threonine-protein kinase PLK4
6 Activities
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1 – 6 of 6
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 7.8 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Ki | 8.38 | J. Med. Chem., (2013) 56:15:6069 | ||||
Ki | 8.38 | J. Med. Chem., (2015) 58:1:130 | ||||
Ki | 8.38 | Eur. J. Med. Chem., (2015) 95:None:35 | ||||
IC50 | 7.34000015 | |||||
Ki | 8.38 | |||||
KIT
Mast/stem cell growth factor receptor Kit
5 Activities
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1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 8.46 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.49 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.77 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.85 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 9.31 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
AURKB
Aurora kinase B
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 7.96 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.96 | |||||
AURKC
Aurora kinase C
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 8.89 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.89 | |||||
FLT1
Vascular endothelial growth factor receptor 1
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 8.24 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.24 | INHIBITOR | ||||
CSF1R
Macrophage colony-stimulating factor 1 receptor
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 7.68 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
PDGFRA
Platelet-derived growth factor receptor alpha
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 9.29 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
PDGFRB
Platelet-derived growth factor receptor beta
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 9.24 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
FLT4
Vascular endothelial growth factor receptor 3
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 6.77 | INHIBITOR | ||||