avatrombopag
Ligand Summary
Avatrombopag is an orally bioavailable, small molecule TPO receptor agonist that stimulates proliferation and differentiation of megakaryocytes from bone marrow progenitor cells resulting in an increased production of platelets. Avatrombopag does not compete with TPO for binding to the TPO receptor and has an additive effect with TPO on platelet production.
UNII: 3H8GSZ4SQL
PubChem: 9852519
ChEMBL: CHEMBL2103883
DrugCentral: 5285
LyCHI: 85DHWNNHF98L
Target Activities
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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EC50 | AGONIST | |||||