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apixaban

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
Apixaban is a selective inhibitor of FXa. It does not require antithrombin III for antithrombotic activity. Apixaban inhibits free and clot-bound FXa, and prothrombinase activity. Apixaban has no direct effect on platelet aggregation, but indirectly inhibits platelet aggregation induced by thrombin. By inhibiting FXa, apixaban decreases thrombin generation and thrombus development.
Synonyms & Links
Guide to Pharmacology: 6390
DrugCentral: 4298
LyCHI:  K9R389ZL42D1


Target Activities