Pharos : Ligand Details - androstenedione

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A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.

Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

UNII: 409J2J96VR

PubChem: 6128

Guide to Pharmacology: 2860

ChEMBL: CHEMBL274826

DrugCentral: 215

LyCHI: FSFMVRT8XQ4Z

Target Activities

Explore Associated and Predicted Targets

HSD17B3

Tchem

Testosterone 17-beta-dehydrogenase 3

6 Activities

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1 – 6 of 6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.31		J. Med. Chem., (2002) 45:3:640	11806715

IC50	6.19		J. Med. Chem., (2002) 45:3:640	11806715

IC50	6.12		J. Med. Chem., (2002) 45:3:640	11806715

IC50	6.12		Bioorg. Med. Chem. Lett., (2000) 10:22:2533	11086723

IC50	6.12		J. Med. Chem., (2005) 48:16:5257	16078844

IC50	6.31		https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL274826

CYP19A1

Tclin

Aromatase

3 Activities

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1 – 3 of 3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.7		J. Med. Chem., (1994) 37:14:2198	8035427

Ki	7.46		Eur. J. Med. Chem., (2015) 105:None:1	26469743

IC50	6.52		J. Med. Chem., (1994) 37:14:2198	8035427

SHBG

Tchem

Sex hormone-binding globulin

2 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.46		J. Med. Chem., (2008) 51:7:2047	18330978

Kd	7.46		https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL274826

AR

Tclin

Androgen receptor

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
	8.56			14565775