androstenedione
A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.
Ligand Summary
UNII: 409J2J96VR
PubChem: 6128
Guide to Pharmacology: 2860
ChEMBL: CHEMBL274826
DrugCentral: 215
LyCHI: FSFMVRT8XQ4Z
Target Activities
HSD17B3
Testosterone 17-beta-dehydrogenase 3
6 Activities
Items per page:
1 – 6 of 6
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 6.31 | J. Med. Chem., (2002) 45:3:640 | ||||
IC50 | 6.19 | J. Med. Chem., (2002) 45:3:640 | ||||
IC50 | 6.12 | J. Med. Chem., (2002) 45:3:640 | ||||
IC50 | 6.12 | Bioorg. Med. Chem. Lett., (2000) 10:22:2533 | ||||
IC50 | 6.12 | J. Med. Chem., (2005) 48:16:5257 | ||||
IC50 | 6.31 | |||||
CYP19A1
Aromatase
3 Activities
SHBG
Sex hormone-binding globulin
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.46 | J. Med. Chem., (2008) 51:7:2047 | ||||
Kd | 7.46 | |||||
AR
Androgen receptor
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
8.56 | ||||||