amrinone
Ligand Summary
A positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator properties, phosphodiesterase 3 inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.
UNII: JUT23379TN
PubChem: 3698
Guide to Pharmacology: 7202
ChEMBL: CHEMBL12856
DrugCentral: 201
LyCHI: DCWWW3BX6XVT
Target Activities
PDE3A
cGMP-inhibited 3',5'-cyclic phosphodiesterase A
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 4.8 | |||||
IC50 | 4.78 | INHIBITOR | ||||
PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase B
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 4.51 | |||||