amlexanox
The mechanism of action by which amlexanox accelerates healing of aphthous ulcers is unknown. In vitro studies have demonstrated amlexanox to be a potent inhibitor of the formation and/or release of inflammatory mediators (histamine and leukotrienes) from mast cells, neutrophils and mononuclear cells.
Ligand Summary
Target Activities
PDE4A
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
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PDE4B
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
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PDE4C
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
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PDE4D
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
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