Pharos : Ligand Details - aminopicoline

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Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

UNII: 394N1Z644H

PubChem: 1533

Guide to Pharmacology: 5111

ChEMBL: CHEMBL40833

DrugCentral: 172

LyCHI: CVANRPTXYWSV

Target Activities

Explore Associated and Predicted Targets

NOS2

Tchem

Nitric oxide synthase, inducible

6 Activities

Items per page:

1 – 6 of 6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.4			8937711

IC50	8		J. Med. Chem., (2004) 47:6:1575	14998342

IC50	6.92		J. Med. Chem., (2004) 47:12:3320	15163211

IC50	6.92		Nat. Chem. Biol., (2008) 4:11:700	18849972

IC50	6.77		Bioorg. Med. Chem. Lett., (2000) 10:17:1975	10987430

IC50	7.4	INHIBITOR	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5111

NOS1

Tchem

Nitric oxide synthase, brain

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.4		J. Med. Chem., (2004) 47:6:1575	14998342

IC50	7.12		Bioorg. Med. Chem. Lett., (2000) 10:17:1975	10987430

IC50	6.96		J. Med. Chem., (2004) 47:12:3320	15163211

IC50	6.8		Nat. Chem. Biol., (2008) 4:11:700	18849972

NOS3

Tchem

Nitric oxide synthase, endothelial

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.14		Bioorg. Med. Chem. Lett., (2000) 10:17:1975	10987430

IC50	7		J. Med. Chem., (2004) 47:6:1575	14998342

IC50	6.52		J. Med. Chem., (2004) 47:12:3320	15163211

IC50	6.5		Nat. Chem. Biol., (2008) 4:11:700	18849972