Pharos : Ligand Details - alitretinoin

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A retinoid that is used for the treatment of chronic hand ECZEMA unresponsive to topical CORTICOSTEROIDS. It is also used to treat cutaneous lesions associated with AIDS-related KAPOSI SARCOMA.

Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

UNII: 1UA8E65KDZ

PubChem: 449171

Guide to Pharmacology: 2645

Guide to Pharmacology: 5383

ChEMBL: CHEMBL705

DrugCentral: 3862

LyCHI: AAMX7XXM488N

Target Activities

Explore Associated and Predicted Targets

RXRA

Tclin

Retinoic acid receptor RXR-alpha

26 Activities

Items per page:

1 – 10 of 26

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.8			8380496

EC50	8.82		J. Med. Chem., (2001) 44:14:2298	11428923

Kd	8.82		J. Med. Chem., (2005) 48:20:6212	16190748

Kd	8.52		J. Med. Chem., (1996) 39:19:3625	8809153

EC50	8.22		J. Med. Chem., (1995) 38:17:3368	7650690

AC50	8.15		Bioorg. Med. Chem. Lett., (2000) 10:12:1307	10890152

Kd	8.1		Bioorg. Med. Chem. Lett., (2003) 13:2:261	12482435

Ki	8.1		J. Med. Chem., (1996) 39:17:3229	8765503

Kd	8.1		Bioorg. Med. Chem. Lett., (1999) 9:4:589	10098670

Ki	8.08		J. Med. Chem., (1996) 39:14:2659	8709094

RARB

Tclin

Retinoic acid receptor beta

23 Activities

Items per page:

1 – 10 of 23

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
-	9.7			10964567 7791761

Kd	9.4			8380496

Ki	9.3		Bioorg. Med. Chem. Lett., (1997) 7:17:2313

Ki	9.15		Bioorg. Med. Chem. Lett., (1997) 7:17:2313

AC50	8.7		Bioorg. Med. Chem. Lett., (2000) 10:12:1307	10890152

EC50	8.52		J. Med. Chem., (2001) 44:14:2298	11428923

EC50	8.48		Bioorg. Med. Chem. Lett., (1994) 4:12:1447

EC50	8.48		J. Med. Chem., (1995) 38:15:2820	7636843

EC50	8.48		J. Med. Chem., (1999) 42:24:4961	10585206

Kd	8.15		Bioorg. Med. Chem. Lett., (1996) 6:2:213

RARG

Tclin

Retinoic acid receptor gamma

20 Activities

Items per page:

1 – 10 of 20

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
-	9			10964567 7791761

Kd	9.2			8380496

Kd	9.1		J. Med. Chem., (2005) 48:20:6212	16190748

Ki	9		J. Med. Chem., (1997) 40:26:4222	9435893

AC50	8.52		Bioorg. Med. Chem. Lett., (2000) 10:12:1307	10890152

EC50	8.4		J. Med. Chem., (2001) 44:14:2298	11428923

EC50	8.22		Bioorg. Med. Chem. Lett., (1994) 4:12:1447

EC50	8.22		J. Med. Chem., (1995) 38:15:2820	7636843

EC50	8.22		J. Med. Chem., (1999) 42:24:4961	10585206

EC50	7.92		J. Med. Chem., (1993) 36:18:2605	8410972

RARA

Tclin

Retinoic acid receptor alpha

13 Activities

Items per page:

1 – 10 of 13

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
	9.5			3184125 7791761

Kd	9.6			8380496

IC50	8.15		J. Med. Chem., (1994) 37:3:408	8308867

Kd	7.96		Bioorg. Med. Chem. Lett., (1996) 6:2:213

AC50	7.72		Bioorg. Med. Chem. Lett., (2000) 10:12:1307	10890152

EC50	7.68		J. Med. Chem., (2001) 44:14:2298	11428923

Ki	7.65		J. Med. Chem., (1996) 39:14:2659	8709094

EC50	7.64		J. Med. Chem., (1995) 38:17:3368	7650690

EC50	7.35		J. Med. Chem., (1993) 36:18:2605	8410972

Kd	7.05		J. Med. Chem., (2001) 44:14:2298	11428923

RXRG

Tclin

Retinoic acid receptor RXR-gamma

13 Activities

Items per page:

1 – 10 of 13

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.9			8380496

IC50	8.4		J. Med. Chem., (1994) 37:3:408	8308867

EC50	8.37		J. Med. Chem., (1995) 38:17:3368	7650690

EC50	8.35		J. Med. Chem., (2001) 44:14:2298	11428923

Ki	7.96		J. Med. Chem., (1997) 40:26:4222	9435893

Ki	7.89		J. Med. Chem., (1996) 39:14:2659	8709094

Ki	7.85		J. Med. Chem., (1996) 39:17:3229	8765503

Kd	7.85		Bioorg. Med. Chem. Lett., (2003) 13:2:261	12482435

Kd	7.85		Bioorg. Med. Chem. Lett., (1999) 9:4:589	10098670

Kd	7.8		Bioorg. Med. Chem. Lett., (1996) 6:2:213

RXRB

Tclin

Retinoic acid receptor RXR-beta

11 Activities

Items per page:

1 – 10 of 11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.7			8380496

EC50	8.59		J. Med. Chem., (1995) 38:17:3368	7650690

Ki	8.42		J. Med. Chem., (1997) 40:26:4222	9435893

Ki	8.13		J. Med. Chem., (1996) 39:14:2659	8709094

Ki	8.05		J. Med. Chem., (1996) 39:17:3229	8765503

Kd	7.96		Bioorg. Med. Chem. Lett., (1996) 6:2:213

IC50	7.92		J. Med. Chem., (1994) 37:3:408	8308867

Kd	7.82		Bioorg. Med. Chem. Lett., (1999) 9:4:589	10098670

EC50	7.54		J. Med. Chem., (2001) 44:14:2298	11428923

Kd	7.46		J. Med. Chem., (2001) 44:14:2298	11428923