alitretinoin
A retinoid that is used for the treatment of chronic hand ECZEMA unresponsive to topical CORTICOSTEROIDS. It is also used to treat cutaneous lesions associated with AIDS-related KAPOSI SARCOMA.
Ligand Summary
Target Activities
RXRA
Retinoic acid receptor RXR-alpha
26 Activities
Items per page:
1 – 10 of 26
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.8 | |||||
EC50 | 8.82 | J. Med. Chem., (2001) 44:14:2298 | ||||
Kd | 8.82 | J. Med. Chem., (2005) 48:20:6212 | ||||
Kd | 8.52 | J. Med. Chem., (1996) 39:19:3625 | ||||
EC50 | 8.22 | J. Med. Chem., (1995) 38:17:3368 | ||||
AC50 | 8.15 | Bioorg. Med. Chem. Lett., (2000) 10:12:1307 | ||||
Kd | 8.1 | Bioorg. Med. Chem. Lett., (2003) 13:2:261 | ||||
Ki | 8.1 | J. Med. Chem., (1996) 39:17:3229 | ||||
Kd | 8.1 | Bioorg. Med. Chem. Lett., (1999) 9:4:589 | ||||
Ki | 8.08 | J. Med. Chem., (1996) 39:14:2659 | ||||
RARB
Retinoic acid receptor beta
23 Activities
Items per page:
1 – 10 of 23
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
- | 9.7 | |||||
Kd | 9.4 | |||||
Ki | 9.3 | Bioorg. Med. Chem. Lett., (1997) 7:17:2313 | ||||
Ki | 9.15 | Bioorg. Med. Chem. Lett., (1997) 7:17:2313 | ||||
AC50 | 8.7 | Bioorg. Med. Chem. Lett., (2000) 10:12:1307 | ||||
EC50 | 8.52 | J. Med. Chem., (2001) 44:14:2298 | ||||
EC50 | 8.48 | Bioorg. Med. Chem. Lett., (1994) 4:12:1447 | ||||
EC50 | 8.48 | J. Med. Chem., (1995) 38:15:2820 | ||||
EC50 | 8.48 | J. Med. Chem., (1999) 42:24:4961 | ||||
Kd | 8.15 | Bioorg. Med. Chem. Lett., (1996) 6:2:213 | ||||
RARG
Retinoic acid receptor gamma
20 Activities
Items per page:
1 – 10 of 20
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
- | 9 | |||||
Kd | 9.2 | |||||
Kd | 9.1 | J. Med. Chem., (2005) 48:20:6212 | ||||
Ki | 9 | J. Med. Chem., (1997) 40:26:4222 | ||||
AC50 | 8.52 | Bioorg. Med. Chem. Lett., (2000) 10:12:1307 | ||||
EC50 | 8.4 | J. Med. Chem., (2001) 44:14:2298 | ||||
EC50 | 8.22 | Bioorg. Med. Chem. Lett., (1994) 4:12:1447 | ||||
EC50 | 8.22 | J. Med. Chem., (1995) 38:15:2820 | ||||
EC50 | 8.22 | J. Med. Chem., (1999) 42:24:4961 | ||||
EC50 | 7.92 | J. Med. Chem., (1993) 36:18:2605 | ||||
RARA
Retinoic acid receptor alpha
13 Activities
Items per page:
1 – 10 of 13
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
9.5 | ||||||
Kd | 9.6 | |||||
IC50 | 8.15 | J. Med. Chem., (1994) 37:3:408 | ||||
Kd | 7.96 | Bioorg. Med. Chem. Lett., (1996) 6:2:213 | ||||
AC50 | 7.72 | Bioorg. Med. Chem. Lett., (2000) 10:12:1307 | ||||
EC50 | 7.68 | J. Med. Chem., (2001) 44:14:2298 | ||||
Ki | 7.65 | J. Med. Chem., (1996) 39:14:2659 | ||||
EC50 | 7.64 | J. Med. Chem., (1995) 38:17:3368 | ||||
EC50 | 7.35 | J. Med. Chem., (1993) 36:18:2605 | ||||
Kd | 7.05 | J. Med. Chem., (2001) 44:14:2298 | ||||
RXRG
Retinoic acid receptor RXR-gamma
13 Activities
Items per page:
1 – 10 of 13
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.9 | |||||
IC50 | 8.4 | J. Med. Chem., (1994) 37:3:408 | ||||
EC50 | 8.37 | J. Med. Chem., (1995) 38:17:3368 | ||||
EC50 | 8.35 | J. Med. Chem., (2001) 44:14:2298 | ||||
Ki | 7.96 | J. Med. Chem., (1997) 40:26:4222 | ||||
Ki | 7.89 | J. Med. Chem., (1996) 39:14:2659 | ||||
Ki | 7.85 | J. Med. Chem., (1996) 39:17:3229 | ||||
Kd | 7.85 | Bioorg. Med. Chem. Lett., (2003) 13:2:261 | ||||
Kd | 7.85 | Bioorg. Med. Chem. Lett., (1999) 9:4:589 | ||||
Kd | 7.8 | Bioorg. Med. Chem. Lett., (1996) 6:2:213 | ||||
RXRB
Retinoic acid receptor RXR-beta
11 Activities
Items per page:
1 – 10 of 11
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.7 | |||||
EC50 | 8.59 | J. Med. Chem., (1995) 38:17:3368 | ||||
Ki | 8.42 | J. Med. Chem., (1997) 40:26:4222 | ||||
Ki | 8.13 | J. Med. Chem., (1996) 39:14:2659 | ||||
Ki | 8.05 | J. Med. Chem., (1996) 39:17:3229 | ||||
Kd | 7.96 | Bioorg. Med. Chem. Lett., (1996) 6:2:213 | ||||
IC50 | 7.92 | J. Med. Chem., (1994) 37:3:408 | ||||
Kd | 7.82 | Bioorg. Med. Chem. Lett., (1999) 9:4:589 | ||||
EC50 | 7.54 | J. Med. Chem., (2001) 44:14:2298 | ||||
Kd | 7.46 | J. Med. Chem., (2001) 44:14:2298 | ||||