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alectinib

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
Alectinib is a tyrosine kinase inhibitor that targets ALK and RET. In nonclinical studies, alectinib inhibited ALK phosphorylation and ALK-mediated activation of the downstream signaling proteins STAT3 and AKT, and decreased tumor cell viability in multiple cell lines harboring ALK fusions, amplifications, or activating mutations. The major active metabolite of alectinib, M4, showed similar in vitro potency and activity.
Synonyms & Links
Guide to Pharmacology: 7739
DrugCentral: 4937
LyCHI:  CBZSLNV1JKXP


Target Activities