acamprosate
The mechanism of action of acamprosate in maintenance of alcohol abstinence is not completely understood. Chronic alcohol exposure is hypothesized to alter the normal balance between neuronal excitation and inhibition. In vitro and in vivo studies in animals have provided evidence to suggest acamprosate may interact with glutamate and GABA neurotransmitter systems centrally, and has led to the hypothesis that acamprosate restores this balance.
Ligand Summary
Target Activities
GRIN2D
Glutamate receptor ionotropic, NMDA 2D
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GRIN3B
Glutamate receptor ionotropic, NMDA 3B
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GRIN1
Glutamate receptor ionotropic, NMDA 1
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GRIN2A
Glutamate receptor ionotropic, NMDA 2A
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GRIN2B
Glutamate receptor ionotropic, NMDA 2B
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GRIN2C
Glutamate receptor ionotropic, NMDA 2C
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GRIN3A
Glutamate receptor ionotropic, NMDA 3A
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GABRA1
Gamma-aminobutyric acid receptor subunit alpha-1
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GABRG2
Gamma-aminobutyric acid receptor subunit gamma-2
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GABRB3
Gamma-aminobutyric acid receptor subunit beta-3
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