abaloparatide
Abaloparatide is a PTHrP(1-34) analog which acts as an agonist at the PTH1 receptor (PTH1R). This results in activation of the cAMP signaling pathway in target cells. In rats and monkeys, abaloparatide had an anabolic effect on bone, demonstrated by increases in BMD and bone mineral content (BMC) that correlated with increases in bone strength at vertebral and/or nonvertebral sites.
Ligand Summary
PubChem: 76943386
ChEMBL: CHEMBL3301581
ChEMBL: CHEMBL4084894
DrugCentral: 5232
LyCHI: T1LQ6VUP9XK8
Target Activities
PTH1R
Parathyroid hormone/parathyroid hormone-related peptide receptor
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
EC50 | 10.7 | J Med Chem, (2017) 60:21:8816 | ||||
IC50 | 9.7 | AGONIST | ||||