Pharos : Ligand Details - Z85XBXPC167T

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Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

Name: N-(2-Chloro-5-(4-morpholinoquinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide

PubChem: 44608915

ChEMBL: CHEMBL1738719

LyCHI: Z85XBXPC167T

Target Activities

Explore Associated and Predicted Targets

PIK3CA

Tclin

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

3 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	9.22		J. Med. Chem., (2011) 54:13:4735	21612232

IC50	8.34		J. Med. Chem., (2011) 54:13:4735	21612232

IC50	7.8		J. Med. Chem., (2011) 54:13:4735	21612232

PRKDC

Tchem

DNA-dependent protein kinase catalytic subunit

1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.64		J. Med. Chem., (2011) 54:13:4735	21612232

PIK3CB

Tchem

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.89		J. Med. Chem., (2011) 54:13:4735	21612232

MTOR

Tclin

Serine/threonine-protein kinase mTOR

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.41		J. Med. Chem., (2011) 54:13:4735	21612232

PIK3C3

Tchem

Phosphatidylinositol 3-kinase catalytic subunit type 3

1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.96		J. Med. Chem., (2011) 54:13:4735	21612232

PIK3CD

Tclin

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.37		J. Med. Chem., (2011) 54:13:4735	21612232

PIK3CG

Tclin

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.09		J. Med. Chem., (2011) 54:13:4735	21612232