CGS-27023
Ligand Summary
Name: CGS-27023
PubChem: 446504
PubChem: 9888897
Guide to Pharmacology: 8846
ChEMBL: CHEMBL514138
ChEMBL: CHEMBL267178
LyCHI: Z6UVRWJRVBAX
Target Activities
MMP9
Matrix metalloproteinase-9
34 Activities
Items per page:
1 – 10 of 34
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.32 | |||||
IC50 | 8.37 | J. Med. Chem., (1999) 42:22:4547 | ||||
IC50 | 8.37 | J. Med. Chem., (1999) 42:1:87 | ||||
IC50 | 8.37 | J. Med. Chem., (1998) 41:19:3568 | ||||
IC50 | 8.37 | Bioorg. Med. Chem. Lett., (2001) 11:8:1009 | ||||
IC50 | 8.32 | Bioorg. Med. Chem., (2007) 15:6:2298 | ||||
IC50 | 8.32 | J. Med. Chem., (2010) 53:6:2622 | ||||
IC50 | 8.32 | Eur. J. Med. Chem., (2011) 46:7:2617 | ||||
IC50 | 8.32 | Bioorg Med Chem, (2019) 27:1:196 | ||||
IC50 | 8.3 | Bioorg. Med. Chem., (2007) 15:3:1266 | ||||
MMP1
Interstitial collagenase
32 Activities
Items per page:
1 – 10 of 32
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.25 | |||||
IC50 | 8.6 | Bioorg. Med. Chem. Lett., (2004) 14:13:3389 | ||||
IC50 | 7.82 | Bioorg. Med. Chem. Lett., (2001) 11:2:235 | ||||
IC50 | 7.82 | J. Med. Chem., (2003) 46:12:2361 | ||||
IC50 | 7.82 | Bioorg. Med. Chem. Lett., (1998) 8:19:2657 | ||||
IC50 | 7.82 | J. Med. Chem., (2003) 46:12:2376 | ||||
IC50 | 7.82 | Bioorg. Med. Chem. Lett., (2001) 11:22:2975 | ||||
IC50 | 7.82 | Bioorg. Med. Chem. Lett., (2001) 11:16:2189 | ||||
IC50 | 7.75 | Bioorg. Med. Chem. Lett., (2003) 13:14:2331 | ||||
IC50 | 7.57 | J. Med. Chem., (2004) 47:11:2761 | ||||
MMP2
72 kDa type IV collagenase
25 Activities
Items per page:
1 – 10 of 25
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.6 | |||||
IC50 | 8.7 | Bioorg. Med. Chem. Lett., (2011) 21:21:6440 | ||||
IC50 | 8.52 | J. Med. Chem., (2007) 50:23:5752 | ||||
IC50 | 8.52 | J. Med. Chem., (2012) 55:10:4714 | ||||
IC50 | 8.4 | Bioorg Med Chem, (2019) 27:10:1997 | ||||
IC50 | 8.34 | Bioorg. Med. Chem. Lett., (2001) 11:20:2723 | ||||
IC50 | 8.04 | Bioorg. Med. Chem. Lett., (2001) 11:8:1009 | ||||
IC50 | 8.04 | J. Med. Chem., (1999) 42:1:87 | ||||
IC50 | 8.04 | J. Med. Chem., (1999) 42:22:4547 | ||||
IC50 | 7.82 | J. Med. Chem., (2003) 46:18:3840 | ||||
MMP3
Stromelysin-1
24 Activities
Items per page:
1 – 10 of 24
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.8 | |||||
Kd | 8.15 | Bioorg. Med. Chem. Lett., (2010) 20:1:280 | ||||
IC50 | 7.85 | Bioorg. Med. Chem. Lett., (1999) 9:12:1691 | ||||
IC50 | 7.85 | J. Med. Chem., (2003) 46:18:3840 | ||||
IC50 | 7.8 | Eur. J. Med. Chem., (2011) 46:7:2617 | ||||
IC50 | 7.8 | J. Med. Chem., (2011) 54:24:8289 | ||||
IC50 | 7.77 | J. Med. Chem., (1999) 42:22:4547 | ||||
IC50 | 7.77 | J. Med. Chem., (1999) 42:1:87 | ||||
IC50 | 7.77 | J. Med. Chem., (1998) 41:19:3568 | ||||
IC50 | 7.77 | Bioorg. Med. Chem. Lett., (2001) 11:8:1009 | ||||
MMP13
Collagenase 3
20 Activities
Items per page:
1 – 10 of 20
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.92 | Bioorg. Med. Chem. Lett., (2011) 21:21:6440 | ||||
Ki | 8.9 | J. Med. Chem., (2009) 52:11:3523 | ||||
IC50 | 8.72 | J. Med. Chem., (2009) 52:11:3523 | ||||
IC50 | 8.52 | Bioorg. Med. Chem. Lett., (2003) 13:14:2331 | ||||
IC50 | 8.37 | J. Med. Chem., (1999) 42:22:4547 | ||||
IC50 | 8.36 | J. Med. Chem., (2009) 52:11:3523 | ||||
IC50 | 8.29 | Bioorg. Med. Chem. Lett., (2001) 11:20:2723 | ||||
IC50 | 8.26 | J. Med. Chem., (2008) 51:24:7968 | ||||
IC50 | 8.1 | Bioorg. Med. Chem. Lett., (2001) 11:2:235 | ||||
IC50 | 8.1 | J. Med. Chem., (2003) 46:12:2361 | ||||
MMP8
Neutrophil collagenase
10 Activities
Items per page:
1 – 10 of 10
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.11 | |||||
IC50 | 8.7 | J. Med. Chem., (2007) 50:23:5752 | ||||
IC50 | 8.7 | J. Med. Chem., (2012) 55:10:4714 | ||||
IC50 | 8.36 | J. Med. Chem., (1999) 42:22:4547 | ||||
IC50 | 8.36 | Bioorg. Med. Chem. Lett., (2001) 11:8:1009 | ||||
IC50 | 8.36 | J. Med. Chem., (1999) 42:1:87 | ||||
IC50 | 8.11 | J. Med. Chem., (2008) 51:24:7968 | ||||
IC50 | 8.11 | Eur. J. Med. Chem., (2011) 46:7:2617 | ||||
IC50 | 8 | Eur J Med Chem, (2017) 138:None:979 | ||||
IC50 | 7.96 | Bioorg Med Chem, (2019) 27:10:1997 | ||||
ADAM17
Disintegrin and metalloproteinase domain-containing protein 17
10 Activities
Items per page:
1 – 10 of 10
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.39 | J. Med. Chem., (2009) 52:11:3523 | ||||
IC50 | 6.96 | J. Med. Chem., (2010) 53:6:2622 | ||||
IC50 | 6.8 | J. Med. Chem., (2010) 53:6:2622 | ||||
IC50 | 6.8 | J. Med. Chem., (2011) 54:24:8289 | ||||
IC50 | 6.64 | Bioorg. Med. Chem. Lett., (2001) 11:22:2975 | ||||
IC50 | 6.64 | Bioorg. Med. Chem. Lett., (2001) 11:16:2189 | ||||
IC50 | 6.64 | J. Med. Chem., (2003) 46:12:2376 | ||||
IC50 | 6.42 | J. Med. Chem., (2010) 53:6:2622 | ||||
IC50 | 6.12 | J. Med. Chem., (2010) 53:6:2622 | ||||
IC50 | 6.12 | J. Med. Chem., (2010) 53:6:2622 | ||||
MMP14
Matrix metalloproteinase-14
8 Activities
Items per page:
1 – 8 of 8
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.64 | |||||
IC50 | 8.12 | J. Med. Chem., (2009) 52:11:3523 | ||||
IC50 | 8.05 | Bioorg. Med. Chem. Lett., (2005) 15:5:1321 | ||||
IC50 | 7.64 | Bioorg. Med. Chem., (2007) 15:3:1266 | ||||
IC50 | 7.64 | J. Med. Chem., (2010) 53:6:2622 | ||||
IC50 | 7.64 | Eur. J. Med. Chem., (2011) 46:7:2617 | ||||
IC50 | 7.64 | Bioorg Med Chem, (2019) 27:1:196 | ||||
IC50 | 7.63 | J. Med. Chem., (2008) 51:24:7968 | ||||
MMP7
Matrilysin
8 Activities
Items per page:
1 – 8 of 8
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7 | Bioorg. Med. Chem. Lett., (2005) 15:5:1321 | ||||
IC50 | 7 | Bioorg. Med. Chem., (2007) 15:3:1266 | ||||
IC50 | 6.97 | Bioorg. Med. Chem. Lett., (2001) 11:8:1009 | ||||
IC50 | 6.97 | J. Med. Chem., (1999) 42:22:4547 | ||||
IC50 | 6.97 | J. Med. Chem., (1999) 42:1:87 | ||||
IC50 | 6.97 | J. Med. Chem., (1998) 41:19:3568 | ||||
IC50 | 6.42 | J. Med. Chem., (2011) 54:24:8289 | ||||
IC50 | 6.13 | J. Med. Chem., (2009) 52:11:3523 | ||||
MMP25
Matrix metalloproteinase-25
2 Activities
MMP16
Matrix metalloproteinase-16
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.17 | J. Med. Chem., (2008) 51:24:7968 | ||||
ADAM10
Disintegrin and metalloproteinase domain-containing protein 10
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 6.05 | J. Med. Chem., (2010) 53:6:2622 | ||||