Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

MMP9

Tchem

Matrix metalloproteinase-9

34 Activities

Items per page:

1 – 10 of 34

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.32		21514700

IC50	8.37	J. Med. Chem., (1999) 42:22:4547	10579818

IC50	8.37	J. Med. Chem., (1999) 42:1:87	9888835

IC50	8.37	J. Med. Chem., (1998) 41:19:3568	9733482

IC50	8.37	Bioorg. Med. Chem. Lett., (2001) 11:8:1009	11327577

IC50	8.32	Bioorg. Med. Chem., (2007) 15:6:2298	17276072

IC50	8.32	J. Med. Chem., (2010) 53:6:2622	20180536

IC50	8.32	Eur. J. Med. Chem., (2011) 46:7:2617	21514700

IC50	8.32	Bioorg Med Chem, (2019) 27:1:196	30522899

IC50	8.3	Bioorg. Med. Chem., (2007) 15:3:1266	17127067

MMP1

Tchem

Interstitial collagenase

32 Activities

Items per page:

1 – 10 of 32

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.25		21514700

IC50	8.6	Bioorg. Med. Chem. Lett., (2004) 14:13:3389	15177439

IC50	7.82	Bioorg. Med. Chem. Lett., (2001) 11:2:235	11206467

IC50	7.82	J. Med. Chem., (2003) 46:12:2361	12773041

IC50	7.82	Bioorg. Med. Chem. Lett., (1998) 8:19:2657	9873598

IC50	7.82	J. Med. Chem., (2003) 46:12:2376	12773042

IC50	7.82	Bioorg. Med. Chem. Lett., (2001) 11:22:2975	11677139

IC50	7.82	Bioorg. Med. Chem. Lett., (2001) 11:16:2189	11514167

IC50	7.75	Bioorg. Med. Chem. Lett., (2003) 13:14:2331	12824028

IC50	7.57	J. Med. Chem., (2004) 47:11:2761	15139754

MMP2

Tchem

72 kDa type IV collagenase

25 Activities

Items per page:

1 – 10 of 25

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.6		21514700

IC50	8.7	Bioorg. Med. Chem. Lett., (2011) 21:21:6440	21937229

IC50	8.52	J. Med. Chem., (2007) 50:23:5752	17956082

IC50	8.52	J. Med. Chem., (2012) 55:10:4714	22540974

IC50	8.4	Bioorg Med Chem, (2019) 27:10:1997	30954331

IC50	8.34	Bioorg. Med. Chem. Lett., (2001) 11:20:2723	11591510

IC50	8.04	Bioorg. Med. Chem. Lett., (2001) 11:8:1009	11327577

IC50	8.04	J. Med. Chem., (1999) 42:1:87	9888835

IC50	8.04	J. Med. Chem., (1999) 42:22:4547	10579818

IC50	7.82	J. Med. Chem., (2003) 46:18:3840	12930146

MMP3

Tchem

Stromelysin-1

24 Activities

Items per page:

1 – 10 of 24

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.8		21514700

Kd	8.15	Bioorg. Med. Chem. Lett., (2010) 20:1:280	19942433

IC50	7.85	Bioorg. Med. Chem. Lett., (1999) 9:12:1691	10397503

IC50	7.85	J. Med. Chem., (2003) 46:18:3840	12930146

IC50	7.8	Eur. J. Med. Chem., (2011) 46:7:2617	21514700

IC50	7.8	J. Med. Chem., (2011) 54:24:8289	22017477

IC50	7.77	J. Med. Chem., (1999) 42:22:4547	10579818

IC50	7.77	J. Med. Chem., (1999) 42:1:87	9888835

IC50	7.77	J. Med. Chem., (1998) 41:19:3568	9733482

IC50	7.77	Bioorg. Med. Chem. Lett., (2001) 11:8:1009	11327577

MMP13

Tchem

Collagenase 3

20 Activities

Items per page:

1 – 10 of 20

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.92	Bioorg. Med. Chem. Lett., (2011) 21:21:6440	21937229

Ki	8.9	J. Med. Chem., (2009) 52:11:3523	19422229

IC50	8.72	J. Med. Chem., (2009) 52:11:3523	19422229

IC50	8.52	Bioorg. Med. Chem. Lett., (2003) 13:14:2331	12824028

IC50	8.37	J. Med. Chem., (1999) 42:22:4547	10579818

IC50	8.36	J. Med. Chem., (2009) 52:11:3523	19422229

IC50	8.29	Bioorg. Med. Chem. Lett., (2001) 11:20:2723	11591510

IC50	8.26	J. Med. Chem., (2008) 51:24:7968	19053764

IC50	8.1	Bioorg. Med. Chem. Lett., (2001) 11:2:235	11206467

IC50	8.1	J. Med. Chem., (2003) 46:12:2361	12773041

MMP8

Tchem

Neutrophil collagenase

10 Activities

Items per page:

1 – 10 of 10

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.11		21514700

IC50	8.7	J. Med. Chem., (2007) 50:23:5752	17956082

IC50	8.7	J. Med. Chem., (2012) 55:10:4714	22540974

IC50	8.36	J. Med. Chem., (1999) 42:22:4547	10579818

IC50	8.36	Bioorg. Med. Chem. Lett., (2001) 11:8:1009	11327577

IC50	8.36	J. Med. Chem., (1999) 42:1:87	9888835

IC50	8.11	J. Med. Chem., (2008) 51:24:7968	19053764

IC50	8.11	Eur. J. Med. Chem., (2011) 46:7:2617	21514700

IC50	8	Eur J Med Chem, (2017) 138:None:979	28756264

IC50	7.96	Bioorg Med Chem, (2019) 27:10:1997	30954331

ADAM17

Tchem

Disintegrin and metalloproteinase domain-containing protein 17

10 Activities

Items per page:

1 – 10 of 10

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.39	J. Med. Chem., (2009) 52:11:3523	19422229

IC50	6.96	J. Med. Chem., (2010) 53:6:2622	20180536

IC50	6.8	J. Med. Chem., (2010) 53:6:2622	20180536

IC50	6.8	J. Med. Chem., (2011) 54:24:8289	22017477

IC50	6.64	Bioorg. Med. Chem. Lett., (2001) 11:22:2975	11677139

IC50	6.64	Bioorg. Med. Chem. Lett., (2001) 11:16:2189	11514167

IC50	6.64	J. Med. Chem., (2003) 46:12:2376	12773042

IC50	6.42	J. Med. Chem., (2010) 53:6:2622	20180536

IC50	6.12	J. Med. Chem., (2010) 53:6:2622	20180536

IC50	6.12	J. Med. Chem., (2010) 53:6:2622	20180536

MMP14

Tchem

Matrix metalloproteinase-14

8 Activities

Items per page:

1 – 8 of 8

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.64		21514700

IC50	8.12	J. Med. Chem., (2009) 52:11:3523	19422229

IC50	8.05	Bioorg. Med. Chem. Lett., (2005) 15:5:1321	15713379

IC50	7.64	Bioorg. Med. Chem., (2007) 15:3:1266	17127067

IC50	7.64	J. Med. Chem., (2010) 53:6:2622	20180536

IC50	7.64	Eur. J. Med. Chem., (2011) 46:7:2617	21514700

IC50	7.64	Bioorg Med Chem, (2019) 27:1:196	30522899

IC50	7.63	J. Med. Chem., (2008) 51:24:7968	19053764

MMP7

Tchem

Matrilysin

8 Activities

Items per page:

1 – 8 of 8

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7	Bioorg. Med. Chem. Lett., (2005) 15:5:1321	15713379

IC50	7	Bioorg. Med. Chem., (2007) 15:3:1266	17127067

IC50	6.97	Bioorg. Med. Chem. Lett., (2001) 11:8:1009	11327577

IC50	6.97	J. Med. Chem., (1999) 42:22:4547	10579818

IC50	6.97	J. Med. Chem., (1999) 42:1:87	9888835

IC50	6.97	J. Med. Chem., (1998) 41:19:3568	9733482

IC50	6.42	J. Med. Chem., (2011) 54:24:8289	22017477

IC50	6.13	J. Med. Chem., (2009) 52:11:3523	19422229

MMP25

Tchem

Matrix metalloproteinase-25

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.82		21514700

IC50	8.82	Eur. J. Med. Chem., (2011) 46:7:2617	21514700

MMP16

Tchem

Matrix metalloproteinase-16

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.17		J. Med. Chem., (2008) 51:24:7968	19053764

ADAM10

Tchem

Disintegrin and metalloproteinase domain-containing protein 10

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.05		J. Med. Chem., (2010) 53:6:2622	20180536