Pharos : Ligand Details

Target Activities

MMP1

Tchem

Interstitial collagenase

31 Activities

Items per page:

1 – 10 of 31

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.02	Bioorg. Med. Chem. Lett., (1999) 9:12:1691	10397503

IC50	7.02	J. Med. Chem., (2003) 46:18:3840	12930146

IC50	7.25	J. Med. Chem., (2008) 51:24:7968	19053764

IC50	7.25	J. Med. Chem., (2010) 53:6:2622	20180536

IC50	7.25	Eur. J. Med. Chem., (2011) 46:7:2617	21514700

IC50	7.26	Bioorg. Med. Chem. Lett., (2005) 15:5:1321	15713379

IC50	7.3	J. Med. Chem., (1999) 42:1:87	9888835

IC50	7.3	Bioorg. Med. Chem. Lett., (2001) 11:8:1009	11327577

IC50	7.3	J. Med. Chem., (1998) 41:19:3568	9733482

IC50	7.3	J. Med. Chem., (1999) 42:22:4547	10579818

MMP9

Tchem

Matrix metalloproteinase-9

30 Activities

Items per page:

1 – 10 of 30

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.22	J. Med. Chem., (2005) 48:9:3400	15857146

IC50	8	J. Med. Chem., (2003) 46:18:3840	12930146

IC50	8.05	Bioorg. Med. Chem. Lett., (2001) 11:16:2189	11514167

IC50	8.05	Bioorg. Med. Chem. Lett., (2001) 11:22:2975	11677139

IC50	8.05	Bioorg. Med. Chem. Lett., (2001) 11:2:235	11206467

IC50	8.05	J. Med. Chem., (2003) 46:12:2361	12773041

IC50	8.05	J. Med. Chem., (2003) 46:12:2376	12773042

IC50	8.06	Bioorg. Med. Chem. Lett., (1998) 8:19:2657	9873598

Ki	8.1	J. Med. Chem., (1999) 42:1:87	9888835

Ki	8.1	Bioorg. Med. Chem. Lett., (1999) 9:14:2049	10450979

MMP3

Tchem

Stromelysin-1

22 Activities

Items per page:

1 – 10 of 22

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.37	J. Med. Chem., (1999) 42:1:87	9888835

Ki	7.37	Bioorg. Med. Chem. Lett., (1999) 9:14:2049	10450979

Ki	7.37	J. Med. Chem., (1997) 40:16:2525	9258358

Ki	7.37	J. Med. Chem., (1997) 40:16:2525	9258358

Ki	7.37	J. Med. Chem., (1998) 41:19:3568	9733482

Ki	7.37	J. Med. Chem., (1999) 42:22:4547	10579818

Kd	7.37	Bioorg. Med. Chem. Lett., (2010) 20:1:280	19942433

Ki	7.37	Eur. J. Med. Chem., (2013) 60:None:89	23287054

Ki	7.37	J. Med. Chem., (2000) 43:3:305	10669559

Ki	7.37	Bioorg. Med. Chem. Lett., (2002) 12:19:2667	12217351

MMP2

Tchem

72 kDa type IV collagenase

22 Activities

Items per page:

1 – 10 of 22

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.6	Bioorg. Med. Chem., (2007) 15:6:2298	17276072

IC50	7.6	J. Med. Chem., (2010) 53:6:2622	20180536

IC50	7.6	Eur. J. Med. Chem., (2011) 46:7:2617	21514700

IC50	7.61	J. Med. Chem., (2008) 51:24:7968	19053764

IC50	7.62	Bioorg. Med. Chem., (2007) 15:3:1266	17127067

Ki	7.7	J. Med. Chem., (1999) 42:1:87	9888835

Ki	7.7	Bioorg. Med. Chem. Lett., (1999) 9:14:2049	10450979

Ki	7.7	J. Med. Chem., (1997) 40:16:2525	9258358

Ki	7.7	J. Med. Chem., (1999) 42:22:4547	10579818

IC50	7.7	Bioorg. Med. Chem. Lett., (2006) 16:4:964	16338135

MMP13

Tchem

Collagenase 3

19 Activities

Items per page:

1 – 10 of 19

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.47	J. Med. Chem., (2012) 55:10:4714	22540974

IC50	7.47	J. Med. Chem., (2007) 50:23:5752	17956082

IC50	7.75	Bioorg. Med. Chem. Lett., (2004) 14:13:3389	15177439

IC50	7.92	Bioorg. Med. Chem. Lett., (1999) 9:12:1691	10397503

IC50	7.92	J. Med. Chem., (2003) 46:18:3840	12930146

IC50	8.09	Bioorg. Med. Chem. Lett., (1998) 8:19:2657	9873598

IC50	8.1	Bioorg. Med. Chem. Lett., (2001) 11:16:2189	11514167

IC50	8.1	Bioorg. Med. Chem. Lett., (2001) 11:22:2975	11677139

IC50	8.1	Bioorg. Med. Chem. Lett., (2001) 11:2:235	11206467

IC50	8.1	J. Med. Chem., (2003) 46:12:2361	12773041

ADAM17

Tchem

Disintegrin and metalloproteinase domain-containing protein 17

10 Activities

Items per page:

1 – 10 of 10

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.12	J. Med. Chem., (2010) 53:6:2622	20180536

IC50	6.12	J. Med. Chem., (2010) 53:6:2622	20180536

IC50	6.42	J. Med. Chem., (2010) 53:6:2622	20180536

IC50	6.64	Bioorg. Med. Chem. Lett., (2001) 11:16:2189	11514167

IC50	6.64	Bioorg. Med. Chem. Lett., (2001) 11:22:2975	11677139

IC50	6.64	J. Med. Chem., (2003) 46:12:2376	12773042

IC50	6.8	J. Med. Chem., (2010) 53:6:2622	20180536

IC50	6.8	J. Med. Chem., (2011) 54:24:8289	22017477

IC50	6.96	J. Med. Chem., (2010) 53:6:2622	20180536

IC50	7.39	J. Med. Chem., (2009) 52:11:3523	19422229

MMP8

Tchem

Neutrophil collagenase

8 Activities

Items per page:

1 – 8 of 8

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.11	J. Med. Chem., (2008) 51:24:7968	19053764

IC50	8.11	Eur. J. Med. Chem., (2011) 46:7:2617	21514700

IC50	8.36	J. Med. Chem., (1999) 42:1:87	9888835

IC50	8.36	Bioorg. Med. Chem. Lett., (2001) 11:8:1009	11327577

IC50	8.36	J. Med. Chem., (1999) 42:22:4547	10579818

IC50	8.7	J. Med. Chem., (2012) 55:10:4714	22540974

IC50	8.7	J. Med. Chem., (2007) 50:23:5752	17956082

IC50	8.10999966		21514700

MMP7

Tchem

Matrilysin

8 Activities

Items per page:

1 – 8 of 8

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.13	J. Med. Chem., (2009) 52:11:3523	19422229

IC50	6.42	J. Med. Chem., (2011) 54:24:8289	22017477

IC50	6.97	J. Med. Chem., (1999) 42:1:87	9888835

IC50	6.97	Bioorg. Med. Chem. Lett., (2001) 11:8:1009	11327577

IC50	6.97	J. Med. Chem., (1998) 41:19:3568	9733482

IC50	6.97	J. Med. Chem., (1999) 42:22:4547	10579818

IC50	7	Bioorg. Med. Chem. Lett., (2005) 15:5:1321	15713379

IC50	7	Bioorg. Med. Chem., (2007) 15:3:1266	17127067

MMP14

Tchem

Matrix metalloproteinase-14

7 Activities

Items per page:

1 – 7 of 7

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.63	J. Med. Chem., (2008) 51:24:7968	19053764

IC50	7.64	J. Med. Chem., (2010) 53:6:2622	20180536

IC50	7.64	Eur. J. Med. Chem., (2011) 46:7:2617	21514700

IC50	7.64	Bioorg. Med. Chem., (2007) 15:3:1266	17127067

IC50	8.05	Bioorg. Med. Chem. Lett., (2005) 15:5:1321	15713379

IC50	8.12	J. Med. Chem., (2009) 52:11:3523	19422229

IC50	7.63999987		21514700

MMP25

Tchem

Matrix metalloproteinase-25

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.82	Eur. J. Med. Chem., (2011) 46:7:2617	21514700

IC50	8.81999969		21514700

ADAM10

Tchem

Disintegrin and metalloproteinase domain-containing protein 10

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.05		J. Med. Chem., (2010) 53:6:2622	20180536

MMP16

Tchem

Matrix metalloproteinase-16

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.17		J. Med. Chem., (2008) 51:24:7968	19053764