CHEMBL204357
Ligand Summary
Name: (2R,3S)-N1-((S)-1-(3-phenoxybenzyl)-2-oxoazepan-3-yl)-N4-hydroxy-2-isobutyl-3-propylsuccinamide
PubChem: 9849669
ChEMBL: CHEMBL204357
LyCHI: Z5JANHFVSUF8
Target Activities
APP
Amyloid-beta A4 protein
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.7 | Bioorg. Med. Chem. Lett., (2006) 16:9:2357 | ||||
ADAM17
Disintegrin and metalloproteinase domain-containing protein 17
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Ki | 8.4 | Bioorg. Med. Chem. Lett., (2006) 16:9:2357 | ||||
MMP2
72 kDa type IV collagenase
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.15 | Bioorg. Med. Chem. Lett., (2006) 16:9:2357 | ||||
MMP7
Matrilysin
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 6.18 | Bioorg. Med. Chem. Lett., (2006) 16:9:2357 | ||||
MMP9
Matrix metalloproteinase-9
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.3 | Bioorg. Med. Chem. Lett., (2006) 16:9:2357 | ||||
MMP10
Stromelysin-2
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 6.72 | Bioorg. Med. Chem. Lett., (2006) 16:9:2357 | ||||
MMP13
Collagenase 3
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8 | Bioorg. Med. Chem. Lett., (2006) 16:9:2357 | ||||
MMP1
Interstitial collagenase
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.68 | Bioorg. Med. Chem. Lett., (2006) 16:9:2357 | ||||