CHEMBL4568087
Ligand Summary
Name: N-(1RS,2SR)-2-aminocyclohexyl)-4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl)thiophene-2-carboxamide
PubChem: 59603842
ChEMBL: CHEMBL4568087
LyCHI: YJMJCHB3DJRD
Target Activities
DYRK1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
1 Activities
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IC50 | 8.49 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
CDK2
Cyclin-dependent kinase 2
1 Activities
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IC50 | 8.66 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
PDPK1
3-phosphoinositide-dependent protein kinase 1
1 Activities
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IC50 | 7.7 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
CSF1R
Macrophage colony-stimulating factor 1 receptor
1 Activities
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IC50 | 8.48 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
ABL1
Tyrosine-protein kinase ABL1
1 Activities
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IC50 | 8.89 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
FLT3
Receptor-type tyrosine-protein kinase FLT3
1 Activities
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IC50 | 8.72 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
SRC
Proto-oncogene tyrosine-protein kinase Src
1 Activities
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IC50 | 8.52 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
KDR
Vascular endothelial growth factor receptor 2
1 Activities
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IC50 | 8.46 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
LCK
Tyrosine-protein kinase Lck
1 Activities
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IC50 | 8.41 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
ROCK1
Rho-associated protein kinase 1
1 Activities
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IC50 | 7.77 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
HCK
Tyrosine-protein kinase HCK
1 Activities
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IC50 | 8.55 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
CDK7
Cyclin-dependent kinase 7
1 Activities
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IC50 | 8.39 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
BMX
Cytoplasmic tyrosine-protein kinase BMX
1 Activities
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IC50 | 8.46 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
EPHB2
Ephrin type-B receptor 2
1 Activities
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IC50 | 8.54 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
IRAK1
Interleukin-1 receptor-associated kinase 1
1 Activities
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IC50 | 8.05 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
IKBKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon
1 Activities
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IC50 | 8.15 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
IRAK4
Interleukin-1 receptor-associated kinase 4
1 Activities
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IC50 | 7.64 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
PRKACA
cAMP-dependent protein kinase catalytic subunit alpha
1 Activities
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IC50 | 7.57 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
EPHA8
Ephrin type-A receptor 8
1 Activities
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IC50 | 8.54 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
FGFR2
Fibroblast growth factor receptor 2
1 Activities
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IC50 | 7.96 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
CLK2
Dual specificity protein kinase CLK2
1 Activities
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IC50 | 7.85 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
CHEK1
Serine/threonine-protein kinase Chk1
1 Activities
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IC50 | 8.66 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
RPS6KB1
Ribosomal protein S6 kinase beta-1
1 Activities
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IC50 | 8.1 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
PAK1
Serine/threonine-protein kinase PAK 1
1 Activities
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IC50 | 7.62 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
GSK3B
Glycogen synthase kinase-3 beta
1 Activities
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IC50 | 7.64 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
EPHA3
Ephrin type-A receptor 3
1 Activities
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IC50 | 7.66 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
BRAF
Serine/threonine-protein kinase B-raf
1 Activities
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IC50 | 7.72 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
MINK1
Misshapen-like kinase 1
1 Activities
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IC50 | 8.22 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
NUAK1
NUAK family SNF1-like kinase 1
1 Activities
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IC50 | 8.38 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
NTRK3
NT-3 growth factor receptor
1 Activities
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IC50 | 7.89 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2
1 Activities
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IC50 | 8.51 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
CHEK2
Serine/threonine-protein kinase Chk2
1 Activities
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IC50 | 7.62 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
AURKB
Aurora kinase B
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IC50 | 7.55 | Bioorg Med Chem Lett, (2016) 26:17:4362 |