CHEMBL3426225
Ligand Summary
Name: 3-((4-Amino-1-ethyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
PubChem: 118737057
ChEMBL: CHEMBL3426225
LyCHI: XLAABADJPKPR
Target Activities
BLK
Tyrosine-protein kinase Blk
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 7.72 | J. Med. Chem., (2015) 58:9:3957 | ||||
FYN
Tyrosine-protein kinase Fyn
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 8.3 | J. Med. Chem., (2015) 58:9:3957 | ||||
RAF1
RAF proto-oncogene serine/threonine-protein kinase
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 7.57 | J. Med. Chem., (2015) 58:9:3957 | ||||
SRC
Proto-oncogene tyrosine-protein kinase Src
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.05 | J. Med. Chem., (2015) 58:9:3957 | ||||
EPHA2
Ephrin type-A receptor 2
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 7.8 | J. Med. Chem., (2015) 58:9:3957 | ||||
YES1
Tyrosine-protein kinase Yes
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 9.1 | J. Med. Chem., (2015) 58:9:3957 | ||||
NTRK1
High affinity nerve growth factor receptor
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 7.57 | J. Med. Chem., (2015) 58:9:3957 | ||||
EPHB2
Ephrin type-B receptor 2
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 7.58 | J. Med. Chem., (2015) 58:9:3957 | ||||
BRAF
Serine/threonine-protein kinase B-raf
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 7.82 | J. Med. Chem., (2015) 58:9:3957 | ||||
NR2C2
Nuclear receptor subfamily 2 group C member 2
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 7.21 | J. Med. Chem., (2015) 58:9:3957 | ||||