CHEMBL1767164
Ligand Summary
Name: (R)-2-((1-(4-(4-(3-(azepan-1-yl)propoxy)phenyl)butyl)pyrrolidin-2-yl)methyl)-4-(4-chlorobenzyl)phthalazin-1(2H)-one
PubChem: 17747460
ChEMBL: CHEMBL1767164
LyCHI: XH4NFD8QGT63
Target Activities
HRH1
Histamine H1 receptor
7 Activities
Items per page:
1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 9.1 | J. Med. Chem., (2011) 54:7:2183 | ||||
Kd | 9.1 | Bioorg. Med. Chem., (2012) 20:20:6097 | ||||
Kd | 9.1 | Bioorg Med Chem Lett, (2016) 26:24:5855 | ||||
Ki | 8 | J. Med. Chem., (2011) 54:7:2183 | ||||
Ki | 8 | Bioorg. Med. Chem., (2012) 20:20:6097 | ||||
Ki | 8 | Bioorg Med Chem Lett, (2016) 26:24:5855 | ||||
Ki | 7.8 | J. Med. Chem., (2011) 54:1:26 | ||||
HRH3
Histamine H3 receptor
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 9.6 | J. Med. Chem., (2011) 54:7:2183 | ||||
Ki | 9.6 | Bioorg. Med. Chem., (2012) 20:20:6097 | ||||
Ki | 9.6 | J. Med. Chem., (2011) 54:1:26 | ||||
Ki | 9.6 | Bioorg Med Chem Lett, (2016) 26:24:5855 | ||||
ADRA1A
Alpha-1A adrenergic receptor
3 Activities
ADRA1B
Alpha-1B adrenergic receptor
3 Activities
KCNH2
Potassium voltage-gated channel subfamily H member 2
3 Activities
CYP3A4
Cytochrome P450 3A4
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.52 | J. Med. Chem., (2011) 54:7:2183 | ||||
CYP2D6
Cytochrome P450 2D6
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.4 | J. Med. Chem., (2011) 54:7:2183 | ||||