Pharos : Ligand Details - XCLYS95UPJ79

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Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

Name: Obatoclax

ChEMBL: CHEMBL408194

LyCHI: XCLYS95UPJ79

Target Activities

Explore Associated and Predicted Targets

MCL1

Tchem

Induced myeloid leukemia cell differentiation protein Mcl-1

2 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	6.3		Eur. J. Med. Chem., (2012) 57:None:112	23047228

Ki	6		Proc. Natl. Acad. Sci. U.S.A., (2007) 104:49:19512	18040043

BCL2A1

Tchem

Bcl-2-related protein A1

2 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	6.22		Eur. J. Med. Chem., (2012) 57:None:112	23047228

Ki	6		Proc. Natl. Acad. Sci. U.S.A., (2007) 104:49:19512	18040043

BAD

Tchem

Bcl2-associated agonist of cell death

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	6		Proc. Natl. Acad. Sci. U.S.A., (2007) 104:49:19512	18040043

BCL2L1

Tchem

Bcl-2-like protein 1

1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	6.05		Eur. J. Med. Chem., (2012) 57:None:112	23047228

BCL2L2

Tchem

Bcl-2-like protein 2

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	6		Proc. Natl. Acad. Sci. U.S.A., (2007) 104:49:19512	18040043

BCL2

Tclin

Apoptosis regulator Bcl-2

1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	6.52		Eur. J. Med. Chem., (2012) 57:None:112	23047228

BCL2L10

Tchem

Bcl-2-like protein 10

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	6		Proc. Natl. Acad. Sci. U.S.A., (2007) 104:49:19512	18040043