xanomeline
Ligand Summary
Name: xanomeline
PubChem: 60809
Guide to Pharmacology: 57
ChEMBL: CHEMBL21536
LyCHI: WZGZ1YTXFSVX
Target Activities
CHRM1
Muscarinic acetylcholine receptor M1
13 Activities
Items per page:
1 – 10 of 13
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 8.8 | J. Med. Chem., (2010) 53:17:6386 | ||||
Ki | 8.1 | Bioorg. Med. Chem., (2008) 16:6:3049 | ||||
Ki | 8.1 | J. Med. Chem., (2014) 57:21:9065 | ||||
EC50 | 8 | J. Med. Chem., (2003) 46:20:4273 | ||||
EC50 | 7.88 | J. Med. Chem., (2014) 57:21:9065 | ||||
EC50 | 7.8 | J. Med. Chem., (2014) 57:21:9065 | ||||
IC50 | 7.74 | Bioorg. Med. Chem., (2008) 16:3:1376 | ||||
IC50 | 7.54 | Bioorg. Med. Chem., (2008) 16:3:1376 | ||||
Ki | 7.38 | Bioorg. Med. Chem. Lett., (1999) 9:14:1895 | ||||
EC50 | 7.24 | J. Med. Chem., (2001) 44:26:4563 | ||||
CHRM4
Muscarinic acetylcholine receptor M4
10 Activities
Items per page:
1 – 10 of 10
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 8.22 | ACS Med Chem Lett, (2019) 10:6:941 | ||||
EC50 | 8.21 | J. Med. Chem., (2010) 53:17:6386 | ||||
Ki | 7.95 | J. Med. Chem., (2014) 57:21:9065 | ||||
EC50 | 7.79 | J. Med. Chem., (2014) 57:21:9065 | ||||
EC50 | 7.75 | ACS Med Chem Lett, (2019) 10:6:941 | ||||
IC50 | 7.6 | J. Med. Chem., (2003) 46:20:4273 | ||||
IC50 | 7.6 | J. Med. Chem., (2006) 49:25:7518 | ||||
Ki | 7.4 | J. Med. Chem., (2003) 46:20:4273 | ||||
Ki | 7.4 | J. Med. Chem., (2006) 49:25:7518 | ||||
Ki | 7.14 | J. Med. Chem., (2010) 53:17:6386 | ||||
CHRM2
Muscarinic acetylcholine receptor M2
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.09 | J. Med. Chem., (2014) 57:21:9065 | ||||
Ki | 7.93 | Bioorg. Med. Chem., (2008) 16:6:3049 | ||||
IC50 | 7.9 | J. Med. Chem., (2003) 46:20:4273 | ||||
Ki | 7.3 | J. Med. Chem., (2003) 46:20:4273 | ||||
Ki | 7.3 | J. Med. Chem., (2006) 49:25:7518 | ||||
CHRM3
Muscarinic acetylcholine receptor M3
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.11 | J. Med. Chem., (2014) 57:21:9065 | ||||
Ki | 7.89 | J. Med. Chem., (2010) 53:17:6386 | ||||
Ki | 7.1 | J. Med. Chem., (2003) 46:20:4273 | ||||
Ki | 7.1 | J. Med. Chem., (2006) 49:25:7518 | ||||
CHRM5
Muscarinic acetylcholine receptor M5
3 Activities
HTR1A
5-hydroxytryptamine receptor 1A
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
7.2 | ||||||
HTR1B
5-hydroxytryptamine receptor 1B
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
7.3 | ||||||
HTR1D
5-hydroxytryptamine receptor 1D
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
8.2 | ||||||
HTR1E
5-hydroxytryptamine receptor 1E
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
5.6 | ||||||
HTR1F
5-hydroxytryptamine receptor 1F
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
6.5 | ||||||
HTR2A
5-hydroxytryptamine receptor 2A
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
6.9 | ||||||
HTR2B
5-hydroxytryptamine receptor 2B
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
7.7 | ||||||
HTR2C
5-hydroxytryptamine receptor 2C
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
7.4 | ||||||
HTR6
5-hydroxytryptamine receptor 6
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
5.9 | ||||||
HTR7
5-hydroxytryptamine receptor 7
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
6.9 | ||||||