apitolisib
Ligand Summary
Name: apitolisib
PubChem: 25254071
Guide to Pharmacology: 7888
ChEMBL: CHEMBL1922094
LyCHI: W1H9TAD8VG77
Target Activities
MTOR
Serine/threonine-protein kinase mTOR
5 Activities
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1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.77 | |||||
Kd | 8.48 | J Med Chem, (2017) 60:17:7524 | ||||
Ki | 7.77 | J. Med. Chem., (2011) 54:21:7579 | ||||
Ki | 7.77 | MedChemComm, (2012) 3:11:1337 | ||||
Ki | 7.77 | ACS Med. Chem. Lett., (2016) 7:4:351 | ||||
PIK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
5 Activities
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1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.32 | |||||
Kd | 9.21 | J Med Chem, (2017) 60:17:7524 | ||||
IC50 | 8.32 | J. Med. Chem., (2011) 54:21:7579 | ||||
IC50 | 8.3 | MedChemComm, (2012) 3:11:1337 | ||||
Ki | 8.3 | ACS Med. Chem. Lett., (2016) 7:4:351 | ||||
PIK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
4 Activities
PIK3CD
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
4 Activities
PIK3CG
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
4 Activities
FGR
Tyrosine-protein kinase Fgr
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.16 | |||||
MAP3K9
Mitogen-activated protein kinase kinase kinase 9
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.63 | |||||
SYK
Tyrosine-protein kinase SYK
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.87 | |||||
JAK1
Tyrosine-protein kinase JAK1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 7.58 | Science, (2017) 358:6367:None | ||||