Pharos : Ligand Details - UGZTC753NTF4

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Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

Name: TAK-779

PubChem: 183790

PubChem: 131673802

PubChem: 9873888

Guide to Pharmacology: 783

ChEMBL: CHEMBL41275

ChEMBL: CHEMBL64322

LyCHI: UGZTC753NTF4

Target Activities

Explore Associated and Predicted Targets

CCR2

Tchem

C-C chemokine receptor type 2

28 Activities

Items per page:

1 – 10 of 28

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
	8.2			12954060 10318947

	7.2			12954060

IC50	10.52		J. Biol. Chem., (2007) 282:41:30062	17715128

IC50	10.1		J. Biol. Chem., (2007) 282:41:30062	17715128

IC50	9.6		J. Biol. Chem., (2007) 282:41:30062	17715128

IC50	9.02		Bioorg. Med. Chem., (2015) 23:14:4034	25766632

IC50	9.02		Eur J Med Chem, (2017) 135:None:401	28463783

Ki	8.7		Bioorg. Med. Chem., (2015) 23:14:4034	25766632

Ki	8.58		J. Med. Chem., (2003) 46:19:4070	12954060

Ki	8.38		J. Med. Chem., (2003) 46:19:4070	12954060

CCR5

Tclin

C-C chemokine receptor type 5

16 Activities

Items per page:

1 – 10 of 16

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
-	7.5			16476734

IC50	8.92		J. Med. Chem., (2002) 45:8:1543	11931608

IC50	8.85		J. Med. Chem., (2000) 43:10:2049	10821717

IC50	8.85		Bioorg. Med. Chem. Lett., (2000) 10:16:1803	10969972

Ki	8.85		Bioorg. Med. Chem. Lett., (2001) 11:2:265	11206474

IC50	8.85		J. Med. Chem., (2006) 49:6:2037	16539392

IC50	8.85		J. Med. Chem., (2006) 49:6:2037	16539392

IC50	8.85		Bioorg. Med. Chem. Lett., (2009) 19:6:1830	19237282

IC50	8.85		Bioorg. Med. Chem. Lett., (2011) 21:18:5159	21820898

IC50	8.85		J. Med. Chem., (2012) 55:22:9363	22931505

CCR7

Tchem

C-C chemokine receptor type 7

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.85		J Med Chem, (2020) 63:10:5031	31930920