Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

AURKA

Tchem

Aurora kinase A

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	8.4	None, None:None:None

Kd	7.85	Science, (2017) 358:6367:None	29191878

RET

Tclin

Proto-oncogene tyrosine-protein kinase receptor Ret

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	8.5	None, None:None:None

Kd	7.77	Science, (2017) 358:6367:None	29191878

RPS6KA3

Tchem

Ribosomal protein S6 kinase alpha-3

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8		None, None:None:None

CDK2

Tchem

Cyclin-dependent kinase 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.8		None, None:None:None

PDPK1

Tchem

3-phosphoinositide-dependent protein kinase 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.8		None, None:None:None

FLT1

Tclin

Vascular endothelial growth factor receptor 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8		None, None:None:None

INSR

Tclin

Insulin receptor

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.6		None, None:None:None

KDR

Tclin

Vascular endothelial growth factor receptor 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.8		None, None:None:None

JAK3

Tclin

Tyrosine-protein kinase JAK3

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.6		None, None:None:None

MST1R

Tchem

Macrophage-stimulating protein receptor

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.7		None, None:None:None

PTK2

Tclin

Focal adhesion kinase 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.1		None, None:None:None

FGFR3

Tclin

Fibroblast growth factor receptor 3

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.3		None, None:None:None

JAK2

Tclin

Tyrosine-protein kinase JAK2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.4		None, None:None:None

AAK1

Tchem

AP2-associated protein kinase 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.05		Science, (2017) 358:6367:None	29191878

TYK2

Tclin

Non-receptor tyrosine-protein kinase TYK2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.9		None, None:None:None

FGFR1

Tclin

Fibroblast growth factor receptor 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.7		None, None:None:None

FER

Tclin

Tyrosine-protein kinase Fer

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.5		None, None:None:None

SLK

Tchem

STE20-like serine/threonine-protein kinase

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.7		None, None:None:None

CHEK1

Tchem

Serine/threonine-protein kinase Chk1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.8		None, None:None:None

BMP2K

Tchem

BMP-2-inducible protein kinase

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.82		Science, (2017) 358:6367:None	29191878

STK17A

Tchem

Serine/threonine-protein kinase 17A

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.5		None, None:None:None

MAP4K5

Tchem

Mitogen-activated protein kinase kinase kinase kinase 5

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.6		None, None:None:None

ULK3

Tchem

Serine/threonine-protein kinase ULK3

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.72		Science, (2017) 358:6367:None	29191878

STK24

Tchem

Serine/threonine-protein kinase 24

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.72		Science, (2017) 358:6367:None	29191878

TBK1

Tchem

Serine/threonine-protein kinase TBK1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.9		None, None:None:None

FES

Tclin

Tyrosine-protein kinase Fes/Fps

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.9		None, None:None:None

BMPR2

Tchem

Bone morphogenetic protein receptor type-2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.1		Science, (2017) 358:6367:None	29191878

MARK3

Tchem

MAP/microtubule affinity-regulating kinase 3

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.8		None, None:None:None

LRRK2

Tchem

Leucine-rich repeat serine/threonine-protein kinase 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	9.2		None, None:None:None

NUAK2

Tchem

NUAK family SNF1-like kinase 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.62		Science, (2017) 358:6367:None	29191878

SIK2

Tchem

Serine/threonine-protein kinase SIK2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.96		Science, (2017) 358:6367:None	29191878

MARK4

Tchem

MAP/microtubule affinity-regulating kinase 4

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.05		Science, (2017) 358:6367:None	29191878

ULK1

Tchem

Serine/threonine-protein kinase ULK1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.55		Science, (2017) 358:6367:None	29191878

PRKAA1

Tclin

5'-AMP-activated protein kinase catalytic subunit alpha-1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.7		None, None:None:None

AURKB

Tchem

Aurora kinase B

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.7		Science, (2017) 358:6367:None	29191878

Q6ZSR9

Tchem

Uncharacterized protein FLJ45252

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8		Science, (2017) 358:6367:None	29191878

ITK

Tclin

Tyrosine-protein kinase ITK/TSK

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.4		None, None:None:None

PLK4

Tchem

Serine/threonine-protein kinase PLK4

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.2		None, None:None:None

CDK5

Tchem

Cyclin-dependent-like kinase 5

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.9		None, None:None:None