Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

PKMYT1

Tchem

Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

8 Activities

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1 – 8 of 8

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	9.1	Bioorg Med Chem, (2018) 26:14:4014	29941193

Ki	9.1	Eur J Med Chem, (2019) 161:None:479	30388464

Ki	8.7	Bioorg Med Chem, (2018) 26:14:4014	29941193

Ki	8.7	Eur J Med Chem, (2019) 161:None:479	30388464

Ki	8.7	Eur J Med Chem, (2019) 161:None:479	30388464

IC50	8.15	Bioorg. Med. Chem. Lett., (2012) 22:2:1219	22189141

IC50	8.1	Bioorg Med Chem, (2018) 26:14:4014	29941193

IC50	8.1	Eur J Med Chem, (2019) 161:None:479	30388464

WEE1

Tchem

Wee1-like protein kinase

4 Activities

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1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.62		11719452

Ki	9.3	None, None:None:None

Kd	7.96	J Med Chem, (2017) 60:18:7863	28792760

IC50	7.62	J Med Chem, (2020) 63:23.0:14151	33135887

FGFR1

Tclin

Fibroblast growth factor receptor 1

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.41		9400019

Ki	8.3	None, None:None:None

PDGFRB

Tclin

Platelet-derived growth factor receptor beta

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.01		9400019

Ki	9.1	None, None:None:None

SRC

Tclin

Proto-oncogene tyrosine-protein kinase Src

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	8.08		9400019

IC50	8.05	J. Med. Chem., (2000) 43:16:3134	10956222

ACVR1

Tchem

Activin receptor type-1

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	8.8	None, None:None:None

IC50	7.68	Eur J Med Chem, (2021) 215:None:113252	33601309

EGFR

Tclin

Epidermal growth factor receptor

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.06			9400019

FYN

Tclin

Tyrosine-protein kinase Fyn

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.8		None, None:None:None

CSF1R

Tclin

Macrophage colony-stimulating factor 1 receptor

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	9.2		None, None:None:None

ABL1

Tclin

Tyrosine-protein kinase ABL1

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	9.3		None, None:None:None

PDGFRA

Tclin

Platelet-derived growth factor receptor alpha

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.7		None, None:None:None

KDR

Tclin

Vascular endothelial growth factor receptor 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.1		None, None:None:None

LCK

Tclin

Tyrosine-protein kinase Lck

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.9		None, None:None:None

TNK2

Tclin

Activated CDC42 kinase 1

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.9		None, None:None:None

MAPK14

Tchem

Mitogen-activated protein kinase 14

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.5		None, None:None:None

WEE2

Tchem

Wee1-like protein kinase 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.3		J Med Chem, (2017) 60:18:7863	28792760

MAP4K5

Tchem

Mitogen-activated protein kinase kinase kinase kinase 5

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.1		None, None:None:None

RIPK2

Tchem

Receptor-interacting serine/threonine-protein kinase 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.89		Eur J Med Chem, (2021) 215:None:113252	33601309

BTK

Tclin

Tyrosine-protein kinase BTK

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8		None, None:None:None

TAOK1

Tchem

Serine/threonine-protein kinase TAO1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.2		None, None:None:None

TYRO3

Tchem

Tyrosine-protein kinase receptor TYRO3

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.4		None, None:None:None

NOD2

Tclin

Nucleotide-binding oligomerization domain-containing protein 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.43		Eur J Med Chem, (2021) 215:None:113252	33601309

RET

Tclin

Proto-oncogene tyrosine-protein kinase receptor Ret

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.1		None, None:None:None

MYT1

Tchem

Myelin transcription factor 1

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.14		Eur. J. Med. Chem., (2013) 61:None:41	22770610