CHEMBL79433
Ligand Summary
Name: 1-benzyl-4-(4-(4-chlorophenoxy)phenylsulfonyl)-N-hydroxypiperidine-4-carboxamide
PubChem: 9957653
ChEMBL: CHEMBL79433
LyCHI: TXH76NTZVJXT
Target Activities
ADAMTS5
A disintegrin and metalloproteinase with thrombospondin motifs 5
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 6.38 | Bioorg. Med. Chem. Lett., (2013) 23:7:2106 | ||||
ADAM17
Disintegrin and metalloproteinase domain-containing protein 17
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 6.52 | J. Med. Chem., (2003) 46:12:2376 | ||||
MMP3
Stromelysin-1
1 Activities
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IC50 | 7.26 | J. Med. Chem., (2003) 46:12:2376 | ||||
MMP2
72 kDa type IV collagenase
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 9 | J. Med. Chem., (2003) 46:12:2376 | ||||
MMP9
Matrix metalloproteinase-9
1 Activities
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IC50 | 9 | J. Med. Chem., (2003) 46:12:2376 | ||||
ADAMTS4
A disintegrin and metalloproteinase with thrombospondin motifs 4
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 6 | Bioorg. Med. Chem. Lett., (2013) 23:7:2106 | ||||
MMP8
Neutrophil collagenase
1 Activities
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IC50 | 9 | J. Med. Chem., (2003) 46:12:2376 | ||||
MMP7
Matrilysin
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 6.03 | J. Med. Chem., (2003) 46:12:2376 | ||||
MMP14
Matrix metalloproteinase-14
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 8.15 | J. Med. Chem., (2003) 46:12:2376 | ||||
MMP1
Interstitial collagenase
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 6.1 | J. Med. Chem., (2003) 46:12:2376 | ||||
MMP13
Collagenase 3
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 9 | J. Med. Chem., (2003) 46:12:2376 | ||||