Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

SRC

Tclin

Proto-oncogene tyrosine-protein kinase Src

9 Activities

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1 – 9 of 9

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.57		17064066

IC50	9	Proc. Natl. Acad. Sci. U.S.A., (2007) 104:9:3520	17360676

IC50	8.57	J. Med. Chem., (2006) 49:22:6465	17064066

IC50	8.57	J. Med. Chem., (2010) 53:11:4332	20218623

IC50	8.57	Bioorg. Med. Chem., (2011) 19:8:2517	21459579

IC50	8.57	Eur J Med Chem, (2019) 170:None:55	30878832

IC50	8.52	Proc. Natl. Acad. Sci. U.S.A., (2007) 104:50:19936	18077425

IC50	8.52	Bioorg. Med. Chem., (2009) 17:8:3152	19321350

IC50	8	Bioorg. Med. Chem., (2009) 17:8:3152	19321350

YES1

Tclin

Tyrosine-protein kinase Yes

6 Activities

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1 – 6 of 6

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.4		17064066

IC50	9.15	Bioorg. Med. Chem. Lett., (2013) 23:15:4398	23787099

IC50	8.4	J. Med. Chem., (2006) 49:22:6465	17064066

IC50	8.4	Proc. Natl. Acad. Sci. U.S.A., (2007) 104:50:19936	18077425

IC50	8.4	J. Med. Chem., (2010) 53:11:4332	20218623

IC50	8.21	Bioorg. Med. Chem. Lett., (2013) 23:15:4398	23787099

LCK

Tclin

Tyrosine-protein kinase Lck

3 Activities

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1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.4		17064066

IC50	8.4	Proc. Natl. Acad. Sci. U.S.A., (2007) 104:50:19936	18077425

Kd	8.05	Science, (2017) 358:6367:None	29191878

ABL1

Tclin

Tyrosine-protein kinase ABL1

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.52			17064066

RIPK2

Tchem

Receptor-interacting serine/threonine-protein kinase 2

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.7		Science, (2017) 358:6367:None	29191878

BCR

Tclin

Breakpoint cluster region protein

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.8		Science, (2017) 358:6367:None	29191878

BMPR1B

Tchem

Bone morphogenetic protein receptor type-1B

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.54		Science, (2017) 358:6367:None	29191878

ACVR1

Tchem

Activin receptor type-1

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.4		Science, (2017) 358:6367:None	29191878

EPHA1

Tchem

Ephrin type-A receptor 1

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8		Science, (2017) 358:6367:None	29191878