saracatinib
Ligand Summary
Name: saracatinib
PubChem: 10302451
Guide to Pharmacology: 7731
ChEMBL: CHEMBL217092
LyCHI: TX69WQR41ZXD
Target Activities
SRC
Proto-oncogene tyrosine-protein kinase Src
9 Activities
Items per page:
1 – 9 of 9
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.57 | |||||
IC50 | 9 | Proc. Natl. Acad. Sci. U.S.A., (2007) 104:9:3520 | ||||
IC50 | 8.57 | J. Med. Chem., (2006) 49:22:6465 | ||||
IC50 | 8.57 | J. Med. Chem., (2010) 53:11:4332 | ||||
IC50 | 8.57 | Bioorg. Med. Chem., (2011) 19:8:2517 | ||||
IC50 | 8.57 | Eur J Med Chem, (2019) 170:None:55 | ||||
IC50 | 8.52 | Proc. Natl. Acad. Sci. U.S.A., (2007) 104:50:19936 | ||||
IC50 | 8.52 | Bioorg. Med. Chem., (2009) 17:8:3152 | ||||
IC50 | 8 | Bioorg. Med. Chem., (2009) 17:8:3152 | ||||
YES1
Tyrosine-protein kinase Yes
6 Activities
Items per page:
1 – 6 of 6
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.4 | |||||
IC50 | 9.15 | Bioorg. Med. Chem. Lett., (2013) 23:15:4398 | ||||
IC50 | 8.4 | J. Med. Chem., (2006) 49:22:6465 | ||||
IC50 | 8.4 | Proc. Natl. Acad. Sci. U.S.A., (2007) 104:50:19936 | ||||
IC50 | 8.4 | J. Med. Chem., (2010) 53:11:4332 | ||||
IC50 | 8.21 | Bioorg. Med. Chem. Lett., (2013) 23:15:4398 | ||||
LCK
Tyrosine-protein kinase Lck
3 Activities
ABL1
Tyrosine-protein kinase ABL1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.52 | |||||
RIPK2
Receptor-interacting serine/threonine-protein kinase 2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.7 | Science, (2017) 358:6367:None | ||||
BCR
Breakpoint cluster region protein
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.8 | Science, (2017) 358:6367:None | ||||
BMPR1B
Bone morphogenetic protein receptor type-1B
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Kd | 7.54 | Science, (2017) 358:6367:None | ||||
ACVR1
Activin receptor type-1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.4 | Science, (2017) 358:6367:None | ||||
EPHA1
Ephrin type-A receptor 1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Kd | 8 | Science, (2017) 358:6367:None | ||||