Pharos : Ligand Details - TL9B623NT4L4

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Ligand Summary

Ligand Structure

chemical structure image

Synonyms & Links

Name: radicicol

PubChem: 6323491

ChEMBL: CHEMBL414883

LyCHI: TL9B623NT4L4

Target Activities

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10

1 – 4 of 4

HSP90AA1

Tchem

Heat shock protein HSP 90-alpha

6 Activities

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1 – 6 of 6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.28		Bioorg. Med. Chem. Lett., (2010) 20:24:7503	21106457

IC50	6.82		J. Med. Chem., (2005) 48:13:4212	15974572

Kd	7.72		J. Med. Chem., (1999) 42:2:260	9925731

IC50	7.8		Bioorg. Med. Chem. Lett., (2010) 20:24:7503	21106457

Kd	8.38		J. Med. Chem., (2013) 56:4:1583	23362862

Kd	8.57		J. Med. Chem., (1999) 42:2:260	9925731

HSP90AB1

Tchem

Heat shock protein HSP 90-beta

3 Activities

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1 – 3 of 3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.7		Bioorg. Med. Chem., (2009) 17:6:2225	19017562

IC50	7.72		J. Nat. Prod., (2014) 77:3:618	24495105

Kd	8.66		Eur. J. Med. Chem., (2013) 65:None:464	23770448

PTGS2

Tclin

Prostaglandin G/H synthase 2

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.57		J. Nat. Prod., (2005) 68:7:985	16038536

CBR1

Tchem

Carbonyl reductase [NADPH] 1

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	6.28		Bioorg. Med. Chem., (2009) 17:2:530	19097799