Pharos : Ligand Details - TFYTR8DJGHKM

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Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

Name: MK-0359

PubChem: 9853498

Guide to Pharmacology: 9852

ChEMBL: CHEMBL372575

LyCHI: TFYTR8DJGHKM

Target Activities

Explore Associated and Predicted Targets

PDE4A

Tclin

cAMP-specific 3',5'-cyclic phosphodiesterase 4A

5 Activities

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1 – 5 of 5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.8			17428447

IC50	9		Bioorg. Med. Chem. Lett., (2010) 20:22:6387	20933411

IC50	8.85		Bioorg. Med. Chem. Lett., (2005) 15:23:5241	16168647

IC50	8.85		Bioorg. Med. Chem. Lett., (2008) 18:20:5554	18835163

IC50	8.85		Bioorg. Med. Chem. Lett., (2010) 20:18:5502	20709547

PDE4B

Tclin

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	9.3			17428447

IC50	9.3		Bioorg. Med. Chem. Lett., (2005) 15:23:5241	16168647

IC50	9.3		Bioorg. Med. Chem. Lett., (2010) 20:18:5502	20709547

IC50	9		Bioorg. Med. Chem. Lett., (2010) 20:22:6387	20933411

PDE4D

Tclin

cAMP-specific 3',5'-cyclic phosphodiesterase 4D

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.92			17428447

IC50	9		Bioorg. Med. Chem. Lett., (2010) 20:22:6387	20933411

IC50	8.92		Bioorg. Med. Chem. Lett., (2005) 15:23:5241	16168647

IC50	8.92		Bioorg. Med. Chem. Lett., (2010) 20:18:5502	20709547

PDE4C

Tclin

cAMP-specific 3',5'-cyclic phosphodiesterase 4C

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.04			17428447

IC50	8.04		Bioorg. Med. Chem. Lett., (2005) 15:23:5241	16168647

IC50	8.04		Bioorg. Med. Chem. Lett., (2010) 20:18:5502	20709547

CYP2C9

Tchem

Cytochrome P450 2C9

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.7		Bioorg. Med. Chem. Lett., (2008) 18:4:1407	18207397

IC50	6.7		J. Med. Chem., (2008) 51:18:5471	18686943

IC50	6.7		Bioorg. Med. Chem. Lett., (2009) 19:17:5266	19640717