MK-0359
Ligand Summary
Name: MK-0359
PubChem: 9853498
Guide to Pharmacology: 9852
ChEMBL: CHEMBL372575
LyCHI: TFYTR8DJGHKM
Target Activities
PDE4A
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.8 | |||||
IC50 | 9 | Bioorg. Med. Chem. Lett., (2010) 20:22:6387 | ||||
IC50 | 8.85 | Bioorg. Med. Chem. Lett., (2005) 15:23:5241 | ||||
IC50 | 8.85 | Bioorg. Med. Chem. Lett., (2008) 18:20:5554 | ||||
IC50 | 8.85 | Bioorg. Med. Chem. Lett., (2010) 20:18:5502 | ||||
PDE4B
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 9.3 | |||||
IC50 | 9.3 | Bioorg. Med. Chem. Lett., (2005) 15:23:5241 | ||||
IC50 | 9.3 | Bioorg. Med. Chem. Lett., (2010) 20:18:5502 | ||||
IC50 | 9 | Bioorg. Med. Chem. Lett., (2010) 20:22:6387 | ||||
PDE4D
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.92 | |||||
IC50 | 9 | Bioorg. Med. Chem. Lett., (2010) 20:22:6387 | ||||
IC50 | 8.92 | Bioorg. Med. Chem. Lett., (2005) 15:23:5241 | ||||
IC50 | 8.92 | Bioorg. Med. Chem. Lett., (2010) 20:18:5502 | ||||
PDE4C
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
3 Activities
CYP2C9
Cytochrome P450 2C9
3 Activities
Items per page:
1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 6.7 | Bioorg. Med. Chem. Lett., (2008) 18:4:1407 | ||||
IC50 | 6.7 | J. Med. Chem., (2008) 51:18:5471 | ||||
IC50 | 6.7 | Bioorg. Med. Chem. Lett., (2009) 19:17:5266 | ||||