Pharos : Ligand Details

Target Activities

MMP1

Tchem

Interstitial collagenase

13 Activities

Items per page:

1 – 10 of 13

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.22		14684295

IC50	9.7	J. Med. Chem., (2011) 54:13:4350	21548582

IC50	9.4	Bioorg. Med. Chem., (2008) 16:18:8745	18782669

IC50	8.82	J. Med. Chem., (1998) 41:8:1209	9548812

IC50	8.82	Bioorg. Med. Chem., (2007) 15:14:4753	17512742

IC50	8.7	Bioorg. Med. Chem. Lett., (1995) 5:15:1637

Ki	8.7	Bioorg. Med. Chem. Lett., (1995) 5:4:337

Ki	8.7	Bioorg. Med. Chem. Lett., (1995) 5:4:349

IC50	8.52	Bioorg. Med. Chem. Lett., (2003) 13:10:1783	12729664

IC50	8.48	J. Biol. Chem., (2007) 282:38:27781	17623656

MMP2

Tchem

72 kDa type IV collagenase

13 Activities

Items per page:

1 – 10 of 13

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.15		14684295

IC50	9.98	Bioorg. Med. Chem. Lett., (2003) 13:17:2843	14611841

Ki	9.41	J. Med. Chem., (1998) 41:2:199	9457244

IC50	9.4	Bioorg. Med. Chem. Lett., (2003) 13:10:1783	12729664

IC50	9.4	Bioorg. Med. Chem., (2008) 16:18:8745	18782669

Ki	9.24	Bioorg. Med. Chem. Lett., (2001) 11:4:567	11229773

IC50	9.03	Bioorg. Med. Chem. Lett., (2016) 26:9:2174	27038494

IC50	8.96	J. Med. Chem., (1998) 41:8:1209	9548812

IC50	8.96	Bioorg. Med. Chem., (2007) 15:14:4753	17512742

IC50	8.15	Bioorg. Med. Chem. Lett., (2004) 14:1:47	14684295

MMP9

Tchem

Matrix metalloproteinase-9

12 Activities

Items per page:

1 – 10 of 12

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.82		14684295

IC50	10.3	J. Med. Chem., (2011) 54:13:4350	21548582

IC50	9.7	Bioorg. Med. Chem. Lett., (1995) 5:15:1637

IC50	9.3	J. Med. Chem., (1998) 41:8:1209	9548812

IC50	9.3	Bioorg. Med. Chem., (2007) 15:14:4753	17512742

IC50	9.26	Bioorg. Med. Chem. Lett., (2016) 26:9:2174	27038494

Ki	9.24	J. Med. Chem., (1998) 41:2:199	9457244

IC50	9.22	Bioorg. Med. Chem., (2008) 16:18:8745	18782669

Ki	9.16	Bioorg. Med. Chem. Lett., (1995) 5:4:349

IC50	8.17	J. Biol. Chem., (2007) 282:38:27781	17623656

MMP14

Tchem

Matrix metalloproteinase-14

9 Activities

Items per page:

1 – 9 of 9

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.64		14684295

IC50	9.39	J. Med. Chem., (2011) 54:13:4350	21548582

IC50	8.33	J. Biol. Chem., (2007) 282:38:27781	17623656

IC50	8.33	Eur. J. Med. Chem., (2013) 62:None:379	23376997

IC50	8.28	Bioorg. Med. Chem., (2008) 16:18:8745	18782669

IC50	7.87	J. Med. Chem., (1998) 41:8:1209	9548812

IC50	7.87	Bioorg. Med. Chem., (2007) 15:14:4753	17512742

IC50	7.64	Bioorg. Med. Chem. Lett., (2004) 14:1:47	14684295

IC50	7.64	J. Med. Chem., (2006) 49:2:456	16420030

MMP3

Tchem

Stromelysin-1

9 Activities

Items per page:

1 – 9 of 9

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	9.72	Bioorg. Med. Chem. Lett., (2003) 13:17:2843	14611841

IC50	8.72	J. Med. Chem., (1998) 41:8:1209	9548812

IC50	8.72	Bioorg. Med. Chem., (2007) 15:14:4753	17512742

IC50	8.15	J. Biol. Chem., (2007) 282:38:27781	17623656

IC50	8.12	J. Med. Chem., (2011) 54:13:4350	21548582

Ki	7.58	Bioorg. Med. Chem. Lett., (2001) 11:4:567	11229773

IC50	7.58	Bioorg. Med. Chem., (2008) 16:18:8745	18782669

IC50	7.55	Bioorg. Med. Chem. Lett., (1995) 5:15:1637

Ki	7.34	Bioorg. Med. Chem. Lett., (1995) 5:4:349

MMP12

Tchem

Macrophage metalloelastase

8 Activities

Items per page:

1 – 8 of 8

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.89		14684295

Ki	9.28	MedChemComm, (2013) 4:2:432

IC50	9	J. Med. Chem., (2008) 51:12:3449	18494455

Ki	8.42	MedChemComm, (2013) 4:2:432

IC50	8.29	J. Biol. Chem., (2007) 282:38:27781	17623656

IC50	8.28	ACS Med Chem Lett, (2018) 9:2:137	29456802

IC50	7.89	Bioorg. Med. Chem. Lett., (2004) 14:1:47	14684295

IC50	7.89	J. Med. Chem., (2006) 49:2:456	16420030

ADAM10

Tchem

Disintegrin and metalloproteinase domain-containing protein 10

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.09		15546732

IC50	8.09	Bioorg. Med. Chem. Lett., (2004) 14:24:6071	15546732

IC50	6.58	J. Med. Chem., (2009) 52:18:5732	19715320

ADAM17

Tchem

Disintegrin and metalloproteinase domain-containing protein 17

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.12		15546732

IC50	8.12	Bioorg. Med. Chem. Lett., (2004) 14:24:6071	15546732

IC50	7.88	J. Med. Chem., (2009) 52:18:5732	19715320

ADAM9

Tchem

Disintegrin and metalloproteinase domain-containing protein 9

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	9		15546732

IC50	9	Bioorg. Med. Chem. Lett., (2004) 14:24:6071	15546732

IC50	7.25	J. Med. Chem., (2009) 52:18:5732	19715320

MMP15

Tchem

Matrix metalloproteinase-15

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.1		14684295

IC50	8.22	Bioorg. Med. Chem. Lett., (2004) 14:1:47	14684295

IC50	8.22	J. Med. Chem., (2006) 49:2:456	16420030

MMP16

Tchem

Matrix metalloproteinase-16

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.1		14684295

IC50	8.1	Bioorg. Med. Chem. Lett., (2004) 14:1:47	14684295

IC50	8.1	J. Med. Chem., (2006) 49:2:456	16420030

MMP26

Tchem

Matrix metalloproteinase-26

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.77		14684295

IC50	7.77	Bioorg. Med. Chem. Lett., (2004) 14:1:47	14684295

IC50	7.77	J. Med. Chem., (2006) 49:2:456	16420030

ADAM12

Tchem

Disintegrin and metalloproteinase domain-containing protein 12

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.23		15546732

IC50	8.23	Bioorg. Med. Chem. Lett., (2004) 14:24:6071	15546732

MMP17

Tchem

Matrix metalloproteinase-17

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.47		17623656

IC50	8.47	J. Biol. Chem., (2007) 282:38:27781	17623656

MMP8

Tchem

Neutrophil collagenase

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	9.74	J. Med. Chem., (1998) 41:2:199	9457244

IC50	8.01	J. Biol. Chem., (2007) 282:38:27781	17623656

MMP13

Tchem

Collagenase 3

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.28	J. Biol. Chem., (2007) 282:38:27781	17623656

IC50	8.28	Eur. J. Med. Chem., (2013) 62:None:379	23376997

ADAMTS5

Tchem

A disintegrin and metalloproteinase with thrombospondin motifs 5

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.3		Eur. J. Med. Chem., (2013) 62:None:379	23376997

ADAMTS4

Tchem

A disintegrin and metalloproteinase with thrombospondin motifs 4

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.32		Eur. J. Med. Chem., (2013) 62:None:379	23376997

MMP7

Tchem

Matrilysin

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.48		J. Biol. Chem., (2007) 282:38:27781	17623656