Pharos : Ligand Details

Target Activities

Items per page:

1 – 10 of 19

MMP2

Tchem

72 kDa type IV collagenase

13 Activities

Items per page:

1 – 10 of 13

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8	J. Biol. Chem., (2007) 282:38:27781	17623656

IC50	8	Eur. J. Med. Chem., (2013) 62:None:379	23376997

IC50	8.15	Bioorg. Med. Chem. Lett., (2004) 14:1:47	14684295

IC50	8.15	J. Med. Chem., (2006) 49:2:456	16420030

IC50	8.96	J. Med. Chem., (1998) 41:8:1209	9548812

IC50	8.96	Bioorg. Med. Chem., (2007) 15:14:4753	17512742

IC50	9.03	Bioorg. Med. Chem. Lett., (2016) 26:9:2174	27038494

Ki	9.24	Bioorg. Med. Chem. Lett., (2001) 11:4:567	11229773

IC50	9.4	Bioorg. Med. Chem. Lett., (2003) 13:10:1783	12729664

IC50	9.4	Bioorg. Med. Chem., (2008) 16:18:8745	18782669

MMP1

Tchem

Interstitial collagenase

13 Activities

Items per page:

1 – 10 of 13

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.22	Bioorg. Med. Chem. Lett., (2004) 14:1:47	14684295

IC50	8.22	J. Med. Chem., (2006) 49:2:456	16420030

IC50	8.48	J. Biol. Chem., (2007) 282:38:27781	17623656

IC50	8.48	Eur. J. Med. Chem., (2013) 62:None:379	23376997

IC50	8.52	Bioorg. Med. Chem. Lett., (2003) 13:10:1783	12729664

IC50	8.7	Bioorg. Med. Chem. Lett., (1995) 5:15:1637

Ki	8.7	Bioorg. Med. Chem. Lett., (1995) 5:4:337

Ki	8.7	Bioorg. Med. Chem. Lett., (1995) 5:4:349

IC50	8.82	J. Med. Chem., (1998) 41:8:1209	9548812

IC50	8.82	Bioorg. Med. Chem., (2007) 15:14:4753	17512742

MMP9

Tchem

Matrix metalloproteinase-9

12 Activities

Items per page:

1 – 10 of 12

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.82	Bioorg. Med. Chem. Lett., (2004) 14:1:47	14684295

IC50	7.82	J. Med. Chem., (2006) 49:2:456	16420030

IC50	8.17	J. Biol. Chem., (2007) 282:38:27781	17623656

Ki	9.16	Bioorg. Med. Chem. Lett., (1995) 5:4:349

IC50	9.22	Bioorg. Med. Chem., (2008) 16:18:8745	18782669

Ki	9.24	J. Med. Chem., (1998) 41:2:199	9457244

IC50	9.26	Bioorg. Med. Chem. Lett., (2016) 26:9:2174	27038494

IC50	9.3	J. Med. Chem., (1998) 41:8:1209	9548812

IC50	9.3	Bioorg. Med. Chem., (2007) 15:14:4753	17512742

IC50	9.7	Bioorg. Med. Chem. Lett., (1995) 5:15:1637

MMP3

Tchem

Stromelysin-1

9 Activities

Items per page:

1 – 9 of 9

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.34	Bioorg. Med. Chem. Lett., (1995) 5:4:349

IC50	7.55	Bioorg. Med. Chem. Lett., (1995) 5:15:1637

Ki	7.58	Bioorg. Med. Chem. Lett., (2001) 11:4:567	11229773

IC50	7.58	Bioorg. Med. Chem., (2008) 16:18:8745	18782669

IC50	8.12	J. Med. Chem., (2011) 54:13:4350	21548582

IC50	8.15	J. Biol. Chem., (2007) 282:38:27781	17623656

IC50	8.72	J. Med. Chem., (1998) 41:8:1209	9548812

IC50	8.72	Bioorg. Med. Chem., (2007) 15:14:4753	17512742

IC50	9.72	Bioorg. Med. Chem. Lett., (2003) 13:17:2843	14611841

MMP14

Tchem

Matrix metalloproteinase-14

9 Activities

Items per page:

1 – 9 of 9

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.64	Bioorg. Med. Chem. Lett., (2004) 14:1:47	14684295

IC50	7.64	J. Med. Chem., (2006) 49:2:456	16420030

IC50	7.87	J. Med. Chem., (1998) 41:8:1209	9548812

IC50	7.87	Bioorg. Med. Chem., (2007) 15:14:4753	17512742

IC50	8.28	Bioorg. Med. Chem., (2008) 16:18:8745	18782669

IC50	8.33	J. Biol. Chem., (2007) 282:38:27781	17623656

IC50	8.33	Eur. J. Med. Chem., (2013) 62:None:379	23376997

IC50	9.39	J. Med. Chem., (2011) 54:13:4350	21548582

IC50	7.63999987		14684295

MMP12

Tchem

Macrophage metalloelastase

7 Activities

Items per page:

1 – 7 of 7

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.89	Bioorg. Med. Chem. Lett., (2004) 14:1:47	14684295

IC50	7.89	J. Med. Chem., (2006) 49:2:456	16420030

IC50	8.29	J. Biol. Chem., (2007) 282:38:27781	17623656

Ki	8.42	MedChemComm, (2013) 4:2:432

IC50	9	J. Med. Chem., (2008) 51:12:3449	18494455

Ki	9.28	MedChemComm, (2013) 4:2:432

IC50	7.88999987		14684295

ADAM9

Tchem

Disintegrin and metalloproteinase domain-containing protein 9

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.25	J. Med. Chem., (2009) 52:18:5732	19715320

IC50	9	Bioorg. Med. Chem. Lett., (2004) 14:24:6071	15546732

IC50	9		15546732

MMP26

Tchem

Matrix metalloproteinase-26

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.77	Bioorg. Med. Chem. Lett., (2004) 14:1:47	14684295

IC50	7.77	J. Med. Chem., (2006) 49:2:456	16420030

IC50	7.76999998		14684295

ADAM17

Tchem

Disintegrin and metalloproteinase domain-containing protein 17

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.88	J. Med. Chem., (2009) 52:18:5732	19715320

IC50	8.12	Bioorg. Med. Chem. Lett., (2004) 14:24:6071	15546732

IC50	8.11999989		15546732

ADAM10

Tchem

Disintegrin and metalloproteinase domain-containing protein 10

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.58	J. Med. Chem., (2009) 52:18:5732	19715320

IC50	8.09	Bioorg. Med. Chem. Lett., (2004) 14:24:6071	15546732

IC50	8.09000015		15546732