CHEMBL19611
Ligand Summary
Name: (R)-N1-((S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccinamide
PubChem: 132519
Guide to Pharmacology: 7409
ChEMBL: CHEMBL19611
LyCHI: SWC2P7KY8XKG
Target Activities
MMP2
72 kDa type IV collagenase
13 Activities
Items per page:
1 – 10 of 13
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8 | J. Biol. Chem., (2007) 282:38:27781 | ||||
IC50 | 8 | Eur. J. Med. Chem., (2013) 62:None:379 | ||||
IC50 | 8.15 | Bioorg. Med. Chem. Lett., (2004) 14:1:47 | ||||
IC50 | 8.15 | J. Med. Chem., (2006) 49:2:456 | ||||
IC50 | 8.96 | J. Med. Chem., (1998) 41:8:1209 | ||||
IC50 | 8.96 | Bioorg. Med. Chem., (2007) 15:14:4753 | ||||
IC50 | 9.03 | Bioorg. Med. Chem. Lett., (2016) 26:9:2174 | ||||
Ki | 9.24 | Bioorg. Med. Chem. Lett., (2001) 11:4:567 | ||||
IC50 | 9.4 | Bioorg. Med. Chem. Lett., (2003) 13:10:1783 | ||||
IC50 | 9.4 | Bioorg. Med. Chem., (2008) 16:18:8745 | ||||
MMP1
Interstitial collagenase
13 Activities
Items per page:
1 – 10 of 13
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.22 | Bioorg. Med. Chem. Lett., (2004) 14:1:47 | ||||
IC50 | 8.22 | J. Med. Chem., (2006) 49:2:456 | ||||
IC50 | 8.48 | J. Biol. Chem., (2007) 282:38:27781 | ||||
IC50 | 8.48 | Eur. J. Med. Chem., (2013) 62:None:379 | ||||
IC50 | 8.52 | Bioorg. Med. Chem. Lett., (2003) 13:10:1783 | ||||
IC50 | 8.7 | Bioorg. Med. Chem. Lett., (1995) 5:15:1637 | ||||
Ki | 8.7 | Bioorg. Med. Chem. Lett., (1995) 5:4:337 | ||||
Ki | 8.7 | Bioorg. Med. Chem. Lett., (1995) 5:4:349 | ||||
IC50 | 8.82 | J. Med. Chem., (1998) 41:8:1209 | ||||
IC50 | 8.82 | Bioorg. Med. Chem., (2007) 15:14:4753 | ||||
MMP9
Matrix metalloproteinase-9
12 Activities
Items per page:
1 – 10 of 12
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.82 | Bioorg. Med. Chem. Lett., (2004) 14:1:47 | ||||
IC50 | 7.82 | J. Med. Chem., (2006) 49:2:456 | ||||
IC50 | 8.17 | J. Biol. Chem., (2007) 282:38:27781 | ||||
Ki | 9.16 | Bioorg. Med. Chem. Lett., (1995) 5:4:349 | ||||
IC50 | 9.22 | Bioorg. Med. Chem., (2008) 16:18:8745 | ||||
Ki | 9.24 | J. Med. Chem., (1998) 41:2:199 | ||||
IC50 | 9.26 | Bioorg. Med. Chem. Lett., (2016) 26:9:2174 | ||||
IC50 | 9.3 | J. Med. Chem., (1998) 41:8:1209 | ||||
IC50 | 9.3 | Bioorg. Med. Chem., (2007) 15:14:4753 | ||||
IC50 | 9.7 | Bioorg. Med. Chem. Lett., (1995) 5:15:1637 | ||||
MMP3
Stromelysin-1
9 Activities
Items per page:
1 – 9 of 9
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.34 | Bioorg. Med. Chem. Lett., (1995) 5:4:349 | ||||
IC50 | 7.55 | Bioorg. Med. Chem. Lett., (1995) 5:15:1637 | ||||
Ki | 7.58 | Bioorg. Med. Chem. Lett., (2001) 11:4:567 | ||||
IC50 | 7.58 | Bioorg. Med. Chem., (2008) 16:18:8745 | ||||
IC50 | 8.12 | J. Med. Chem., (2011) 54:13:4350 | ||||
IC50 | 8.15 | J. Biol. Chem., (2007) 282:38:27781 | ||||
IC50 | 8.72 | J. Med. Chem., (1998) 41:8:1209 | ||||
IC50 | 8.72 | Bioorg. Med. Chem., (2007) 15:14:4753 | ||||
IC50 | 9.72 | Bioorg. Med. Chem. Lett., (2003) 13:17:2843 | ||||
MMP14
Matrix metalloproteinase-14
9 Activities
Items per page:
1 – 9 of 9
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.64 | Bioorg. Med. Chem. Lett., (2004) 14:1:47 | ||||
IC50 | 7.64 | J. Med. Chem., (2006) 49:2:456 | ||||
IC50 | 7.87 | J. Med. Chem., (1998) 41:8:1209 | ||||
IC50 | 7.87 | Bioorg. Med. Chem., (2007) 15:14:4753 | ||||
IC50 | 8.28 | Bioorg. Med. Chem., (2008) 16:18:8745 | ||||
IC50 | 8.33 | J. Biol. Chem., (2007) 282:38:27781 | ||||
IC50 | 8.33 | Eur. J. Med. Chem., (2013) 62:None:379 | ||||
IC50 | 9.39 | J. Med. Chem., (2011) 54:13:4350 | ||||
IC50 | 7.63999987 | |||||
MMP12
Macrophage metalloelastase
7 Activities
Items per page:
1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.89 | Bioorg. Med. Chem. Lett., (2004) 14:1:47 | ||||
IC50 | 7.89 | J. Med. Chem., (2006) 49:2:456 | ||||
IC50 | 8.29 | J. Biol. Chem., (2007) 282:38:27781 | ||||
Ki | 8.42 | MedChemComm, (2013) 4:2:432 | ||||
IC50 | 9 | J. Med. Chem., (2008) 51:12:3449 | ||||
Ki | 9.28 | MedChemComm, (2013) 4:2:432 | ||||
IC50 | 7.88999987 | |||||
ADAM9
Disintegrin and metalloproteinase domain-containing protein 9
3 Activities
MMP26
Matrix metalloproteinase-26
3 Activities
ADAM17
Disintegrin and metalloproteinase domain-containing protein 17
3 Activities
ADAM10
Disintegrin and metalloproteinase domain-containing protein 10
3 Activities
MMP16
Matrix metalloproteinase-16
3 Activities
MMP15
Matrix metalloproteinase-15
3 Activities
MMP17
Matrix metalloproteinase-17
2 Activities
MMP8
Neutrophil collagenase
2 Activities
MMP13
Collagenase 3
2 Activities
ADAM12
Disintegrin and metalloproteinase domain-containing protein 12
2 Activities
ADAMTS5
A disintegrin and metalloproteinase with thrombospondin motifs 5
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.3 | Eur. J. Med. Chem., (2013) 62:None:379 | ||||
ADAMTS4
A disintegrin and metalloproteinase with thrombospondin motifs 4
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.32 | Eur. J. Med. Chem., (2013) 62:None:379 | ||||
MMP7
Matrilysin
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.48 | J. Biol. Chem., (2007) 282:38:27781 | ||||