CHEMBL2349526
Ligand Summary
Name: (S)-2-amino-4-(((2S,3S,4R,5R)-5-(4-amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylthio)butanoic acid
PubChem: 53339032
Guide to Pharmacology: 7018
ChEMBL: CHEMBL2349526
LyCHI: R5TF1YWKWHNX
Target Activities
Items per page:
10
1 – 3 of 3
DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific
5 Activities
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1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.11 | J. Med. Chem., (2013) 56:22:8972 | ||||
IC50 | 7.11 | Bioorg. Med. Chem., (2013) 21:7:1787 | ||||
Ki | 7.42 | Bioorg. Med. Chem., (2013) 21:7:1787 | ||||
Ki | 7.42000008 | |||||
IC50 | 7.11000013 | |||||
DNMT1
DNA (cytosine-5)-methyltransferase 1
2 Activities
NNMT
Nicotinamide N-methyltransferase
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 6.12 | Bioorg. Med. Chem., (2013) 21:7:1787 | ||||