Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

PTK2

Tclin

Focal adhesion kinase 1

11 Activities

Items per page:

1 – 10 of 11

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.26		17219439 17431114

Ki	8.8	None, None:None:None

IC50	8.26	Med Chem Res, (2013) None:None:1

IC50	8.26	Eur J Med Chem, (2019) 177:None:32	31129452

IC50	8.21	Eur J Med Chem, (2019) 183:None:111716	31550660

IC50	8.17	Bioorg Med Chem, (2017) 25:15:3989	28576633

IC50	8.17	Bioorg Med Chem, (2017) 25:24:6313	29102081

IC50	8.17	Eur J Med Chem, (2019) 172:None:154	30978560

IC50	8.15	Bioorg. Med. Chem. Lett., (2013) 23:16:4552	23845217

IC50	8.15	J. Med. Chem., (2015) 58:1:237	25180654

IGF1R

Tclin

Insulin-like growth factor 1 receptor

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.85		17431114

Ki	8.4	None, None:None:None

INSR

Tclin

Insulin receptor

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	8.3	None, None:None:None

IC50	7.6	Bioorg. Med. Chem. Lett., (2011) 21:1:463	21074994

MAPK10

Tchem

Mitogen-activated protein kinase 10

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	8.5	None, None:None:None

IC50	7.92	MedChemComm, (2012) 3:2:238

ALK

Tclin

ALK tyrosine kinase receptor

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.3	Bioorg. Med. Chem. Lett., (2011) 21:1:463	21074994

Ki	7.6	None, None:None:None

MAPK8

Tchem

Mitogen-activated protein kinase 8

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.1		None, None:None:None

FER

Tclin

Tyrosine-protein kinase Fer

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8		None, None:None:None

CLK4

Tchem

Dual specificity protein kinase CLK4

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.8		None, None:None:None

FRK

Tchem

Tyrosine-protein kinase FRK

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.7		None, None:None:None

CAMKK2

Tchem

Calcium/calmodulin-dependent protein kinase kinase 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.9		None, None:None:None

ROS1

Tclin

Proto-oncogene tyrosine-protein kinase ROS

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.3		None, None:None:None

LTK

Tclin

Leukocyte tyrosine kinase receptor

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.1		None, None:None:None

LRRK2

Tchem

Leucine-rich repeat serine/threonine-protein kinase 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.6		None, None:None:None

AURKB

Tchem

Aurora kinase B

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.8		None, None:None:None

AURKA

Tchem

Aurora kinase A

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.4		Eur J Med Chem, (2016) 124:None:896	27668758

PLK4

Tchem

Serine/threonine-protein kinase PLK4

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.4		None, None:None:None