Pharos : Ligand Details - R1ZTUCG941LG

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Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

Name: (E)-Norendoxifen

PubChem: 60202715

ChEMBL: CHEMBL2386285

LyCHI: R1ZTUCG941LG

Target Activities

Explore Associated and Predicted Targets

CYP19A1

Tclin

Aromatase

5 Activities

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1 – 5 of 5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.32		J. Med. Chem., (2013) 56:11:4611	23731360

IC50	7.12		J. Med. Chem., (2013) 56:11:4611	23731360

IC50	7.12		Bioorg Med Chem, (2016) 24:21:5400	27647367

IC50	7.05		J. Med. Chem., (2013) 56:11:4611	23731360

IC50	6.99		J. Med. Chem., (2015) 58:6:2623	25751283

ESR2

Tclin

Estrogen receptor beta

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	7.45		J. Med. Chem., (2015) 58:6:2623	25751283

EC50	7.11		J. Med. Chem., (2013) 56:11:4611	23731360

EC50	7.11		Bioorg Med Chem, (2016) 24:21:5400	27647367

ESR1

Tclin

Estrogen receptor

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	7.57		J. Med. Chem., (2015) 58:6:2623	25751283

EC50	7.23		J. Med. Chem., (2013) 56:11:4611	23731360

EC50	7.23		Bioorg Med Chem, (2016) 24:21:5400	27647367

CYP3A4

Tclin

Cytochrome P450 3A4

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.54		J. Med. Chem., (2015) 58:6:2623	25751283

Ki	6.43		J. Med. Chem., (2015) 58:6:2623	25751283

CYP3A5

Tclin

Cytochrome P450 3A5

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.14		J. Med. Chem., (2015) 58:6:2623	25751283

Ki	6.08		J. Med. Chem., (2015) 58:6:2623	25751283

CYP1A2

Tchem

Cytochrome P450 1A2

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.12		J. Med. Chem., (2015) 58:6:2623	25751283

IC50	6.68		J. Med. Chem., (2015) 58:6:2623	25751283