CHEMBL2325014
Ligand Summary
Name: 4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide
PubChem: 46840946
ChEMBL: CHEMBL2325014
LyCHI: QS61BPT29RD6
Target Activities
SCN9A
Sodium channel protein type 9 subunit alpha
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.07 | Bioorg. Med. Chem. Lett., (2013) 23:1:261 | ||||
IC50 | 7.96 | Bioorg Med Chem Lett, (2017) 27:10:2087 | ||||
IC50 | 7.96 | J Med Chem, (2017) 60:16:7029 | ||||
IC50 | 7.96 | Bioorg Med Chem Lett, (2017) 27:21:4805 | ||||
IC50 | 7.51 | Bioorg Med Chem Lett, (2017) 27:10:2210 | ||||
SCN1A
Sodium channel protein type 1 subunit alpha
2 Activities
SCN2A
Sodium channel protein type 2 subunit alpha
2 Activities
SCN8A
Sodium channel protein type 8 subunit alpha
2 Activities
SCN5A
Sodium channel protein type 5 subunit alpha
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.96 | Bioorg Med Chem Lett, (2017) 27:12:2683 | ||||
SCN4A
Sodium channel protein type 4 subunit alpha
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 5 | J Med Chem, (2019) 62:19:8695 | ||||
CYP2C9
Cytochrome P450 2C9
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.52 | J Med Chem, (2017) 60:16:7029 | ||||
SCN7A
Sodium channel protein type 7 subunit alpha
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.96 | J Med Chem, (2019) 62:19:8695 | ||||