Pharos : Ligand Details

Target Activities

SYK

Tclin

Tyrosine-protein kinase SYK

10 Activities

Items per page:

1 – 10 of 10

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.71999979		22037378

IC50	7.76999998		23151054

IC50	8.26	None, (2015) None:None:None

Ki	8.2	None, None:None:None

EC50	8	J. Med. Chem., (2012) 55:8:3614	22257213

EC50	8	J. Med. Chem., (2012) 55:8:3614	22257213

EC50	8	J. Med. Chem., (2012) 55:8:3614	22257213

EC50	8	J. Med. Chem., (2012) 55:8:3614	22257213

Kd	7.72	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	7.63	None, (2015) None:None:None

FLT3

Tclin

Receptor-type tyrosine-protein kinase FLT3

10 Activities

Items per page:

1 – 10 of 10

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	9.43	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.27	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.19	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.17	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.15	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.15	J. Med. Chem., (2013) 56:20:8032	24044867

Kd	8.82	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.36	Nat. Biotechnol., (2011) 29:11:1046	22037378

EC50	8	J. Med. Chem., (2014) 57:9:3856	24779514

Kd	7.75	Science, (2017) 358:6367:None	29191878

RET

Tclin

Proto-oncogene tyrosine-protein kinase receptor Ret

7 Activities

Items per page:

1 – 7 of 7

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.30000019		19107952

Kd	8.66	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.51	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.39	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.39	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	8.3	J. Med. Chem., (2012) 55:8:3614	22257213

Ki	7.9	None, None:None:None

KIT

Tclin

Mast/stem cell growth factor receptor Kit

7 Activities

Items per page:

1 – 7 of 7

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.6	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.46	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.25	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.24	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.19	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.17	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.96	Nat. Biotechnol., (2011) 29:11:1046	22037378

JAK2

Tclin

Tyrosine-protein kinase JAK2

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.46	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	8.22	Bioorg. Med. Chem. Lett., (2014) 24:10:2278	24726806

EC50	7.89	J. Med. Chem., (2014) 57:9:3856	24779514

MAP3K11

Tchem

Mitogen-activated protein kinase kinase kinase 11

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.96	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.96	J. Med. Chem., (2013) 56:20:8032	24044867

Kd	7.54	Science, (2017) 358:6367:None	29191878

BLK

Tchem

Tyrosine-protein kinase Blk

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	8.2	None, None:None:None

Kd	7.6	Nat. Biotechnol., (2011) 29:11:1046	22037378

FLT1

Tclin

Vascular endothelial growth factor receptor 1

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.8	Nat. Biotechnol., (2011) 29:11:1046	22037378

Ki	7.6	None, None:None:None

SRC

Tclin

Proto-oncogene tyrosine-protein kinase Src

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)