Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

SYK

Tclin

Tyrosine-protein kinase SYK

10 Activities

Items per page:

1 – 10 of 10

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.72		22037378

IC50	7.77		23151054

IC50	8.26	None, (2015) None:None:None

Ki	8.2	None, None:None:None

EC50	8	J. Med. Chem., (2012) 55:8:3614	22257213

EC50	8	J. Med. Chem., (2012) 55:8:3614	22257213

EC50	8	J. Med. Chem., (2012) 55:8:3614	22257213

EC50	8	J. Med. Chem., (2012) 55:8:3614	22257213

Kd	7.72	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	7.63	None, (2015) None:None:None

FLT3

Tclin

Receptor-type tyrosine-protein kinase FLT3

10 Activities

Items per page:

1 – 10 of 10

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	9.43	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.27	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.19	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.17	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.15	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.15	J. Med. Chem., (2013) 56:20:8032	24044867

Kd	8.82	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.36	Nat. Biotechnol., (2011) 29:11:1046	22037378

EC50	8	J. Med. Chem., (2014) 57:9:3856	24779514

Kd	7.75	Science, (2017) 358:6367:None	29191878

RET

Tclin

Proto-oncogene tyrosine-protein kinase receptor Ret

7 Activities

Items per page:

1 – 7 of 7

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.3		19107952

Kd	8.66	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.51	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.39	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.39	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	8.3	J. Med. Chem., (2012) 55:8:3614	22257213

Ki	7.9	None, None:None:None

KIT

Tclin

Mast/stem cell growth factor receptor Kit

7 Activities

Items per page:

1 – 7 of 7

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.6	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.46	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.25	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.24	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.19	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.17	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.96	Nat. Biotechnol., (2011) 29:11:1046	22037378

JAK2

Tclin

Tyrosine-protein kinase JAK2

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.46	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	8.22	Bioorg. Med. Chem. Lett., (2014) 24:10:2278	24726806

EC50	7.89	J. Med. Chem., (2014) 57:9:3856	24779514

MAP3K11

Tchem

Mitogen-activated protein kinase kinase kinase 11

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.96	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.96	J. Med. Chem., (2013) 56:20:8032	24044867

Kd	7.54	Science, (2017) 358:6367:None	29191878

BLK

Tchem

Tyrosine-protein kinase Blk

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	8.2	None, None:None:None

Kd	7.6	Nat. Biotechnol., (2011) 29:11:1046	22037378

FLT1

Tclin

Vascular endothelial growth factor receptor 1

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.8	Nat. Biotechnol., (2011) 29:11:1046	22037378

Ki	7.6	None, None:None:None

SRC

Tclin

Proto-oncogene tyrosine-protein kinase Src

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	8.2	None, None:None:None

Kd	8.08	Nat. Biotechnol., (2011) 29:11:1046	22037378

KDR

Tclin

Vascular endothelial growth factor receptor 2

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
IC50	8	None, (2015) None:None:None

Ki	7.7	None, None:None:None

LYN

Tclin

Tyrosine-protein kinase Lyn

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.9	None, None:None:None

Kd	7.58	Nat. Biotechnol., (2011) 29:11:1046	22037378

IRAK1

Tchem

Interleukin-1 receptor-associated kinase 1

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.01	Nat. Biotechnol., (2011) 29:11:1046	22037378

Ki	8	None, None:None:None

ROS1

Tclin

Proto-oncogene tyrosine-protein kinase ROS

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	8.2	None, None:None:None

Kd	7.54	Nat. Biotechnol., (2011) 29:11:1046	22037378

MAP3K10

Tchem

Mitogen-activated protein kinase kinase kinase 10

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.42	Nat. Biotechnol., (2011) 29:11:1046	22037378

Ki	8.4	None, None:None:None

PLK4

Tchem

Serine/threonine-protein kinase PLK4

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.38	Nat. Biotechnol., (2011) 29:11:1046	22037378

Ki	8	None, None:None:None

MAPK8

Tchem

Mitogen-activated protein kinase 8

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	8		J. Med. Chem., (2012) 55:8:3614	22257213

DAPK3

Tchem

Death-associated protein kinase 3

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.89		Nat. Biotechnol., (2011) 29:11:1046	22037378

PDPK1

Tchem

3-phosphoinositide-dependent protein kinase 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.1		None, None:None:None

FYN

Tclin

Tyrosine-protein kinase Fyn

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.55		Nat. Biotechnol., (2011) 29:11:1046	22037378

PDGFRB

Tclin

Platelet-derived growth factor receptor beta

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.48		Nat. Biotechnol., (2011) 29:11:1046	22037378

FLT4

Tclin

Vascular endothelial growth factor receptor 3

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.04		Nat. Biotechnol., (2011) 29:11:1046	22037378

MAPK10

Tchem

Mitogen-activated protein kinase 10

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8		None, None:None:None

FGFR3

Tclin

Fibroblast growth factor receptor 3

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.8		None, None:None:None

ZAP70

Tchem

Tyrosine-protein kinase ZAP-70

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.68		Nat. Biotechnol., (2011) 29:11:1046	22037378

JAK1

Tclin

Tyrosine-protein kinase JAK1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.68		Nat. Biotechnol., (2011) 29:11:1046	22037378

STK16

Tchem

Serine/threonine-protein kinase 16

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.77		Nat. Biotechnol., (2011) 29:11:1046	22037378

IKBKE

Tchem

Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.89		Nat. Biotechnol., (2011) 29:11:1046	22037378

TYK2

Tclin

Non-receptor tyrosine-protein kinase TYK2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.8		None, None:None:None

STK17B

Tchem

Serine/threonine-protein kinase 17B

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.04		Nat. Biotechnol., (2011) 29:11:1046	22037378

FER

Tclin

Tyrosine-protein kinase Fer

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.9		None, None:None:None

CSNK2A2

Tchem

Casein kinase II subunit alpha'

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.85		Nat. Biotechnol., (2011) 29:11:1046	22037378

MAPK9

Tchem

Mitogen-activated protein kinase 9

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	8		J. Med. Chem., (2012) 55:8:3614	22257213

SLK

Tchem

STE20-like serine/threonine-protein kinase

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.6		None, None:None:None

FRK

Tchem

Tyrosine-protein kinase FRK

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.9		None, None:None:None

NEK6

Tchem

Serine/threonine-protein kinase Nek6

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.2		Nat. Biotechnol., (2011) 29:11:1046	22037378

NEK7

Tchem

Serine/threonine-protein kinase Nek7

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.96		Nat. Biotechnol., (2011) 29:11:1046	22037378

PLK3

Tchem

Serine/threonine-protein kinase PLK3

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.29		Nat. Biotechnol., (2011) 29:11:1046	22037378

NEK5

Tchem

Serine/threonine-protein kinase Nek5

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.89		Nat. Biotechnol., (2011) 29:11:1046	22037378

ULK3

Tchem

Serine/threonine-protein kinase ULK3

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.15		Nat. Biotechnol., (2011) 29:11:1046	22037378

IRAK3

Tchem

Interleukin-1 receptor-associated kinase 3

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.96		Nat. Biotechnol., (2011) 29:11:1046	22037378

NEK9

Tchem

Serine/threonine-protein kinase Nek9

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.8		Nat. Biotechnol., (2011) 29:11:1046	22037378

DDR1

Tchem

Epithelial discoidin domain-containing receptor 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.03		Nat. Biotechnol., (2011) 29:11:1046	22037378

TNK1

Tchem

Non-receptor tyrosine-protein kinase TNK1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.6		Nat. Biotechnol., (2011) 29:11:1046	22037378

EIF2AK4

Tchem

eIF-2-alpha kinase GCN2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.48		Nat. Biotechnol., (2011) 29:11:1046	22037378

TBK1

Tchem

Serine/threonine-protein kinase TBK1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.64		Nat. Biotechnol., (2011) 29:11:1046	22037378

ULK2

Tchem

Serine/threonine-protein kinase ULK2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.72		Nat. Biotechnol., (2011) 29:11:1046	22037378

PTK2B

Tclin

Protein-tyrosine kinase 2-beta

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.54		Nat. Biotechnol., (2011) 29:11:1046	22037378

LRRK2

Tchem

Leucine-rich repeat serine/threonine-protein kinase 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.57		Nat. Biotechnol., (2011) 29:11:1046	22037378

SIK2

Tchem

Serine/threonine-protein kinase SIK2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.6		None, None:None:None

ULK1

Tchem

Serine/threonine-protein kinase ULK1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.85		Nat. Biotechnol., (2011) 29:11:1046	22037378

MAP3K9

Tchem

Mitogen-activated protein kinase kinase kinase 9

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.37		Nat. Biotechnol., (2011) 29:11:1046	22037378

MYH10

Tchem

Myosin-10

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	6.64		Science, (2017) 358:6367:None	29191878