tamatinib
Ligand Summary
Name: tamatinib
PubChem: 11213558
Guide to Pharmacology: 5706
ChEMBL: CHEMBL475251
LyCHI: Q44NG3N9YC71
Target Activities
SYK
Tyrosine-protein kinase SYK
10 Activities
Items per page:
1 – 10 of 10
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.72 | |||||
IC50 | 7.77 | |||||
IC50 | 8.26 | None, (2015) None:None:None | ||||
Ki | 8.2 | None, None:None:None | ||||
EC50 | 8 | J. Med. Chem., (2012) 55:8:3614 | ||||
EC50 | 8 | J. Med. Chem., (2012) 55:8:3614 | ||||
EC50 | 8 | J. Med. Chem., (2012) 55:8:3614 | ||||
EC50 | 8 | J. Med. Chem., (2012) 55:8:3614 | ||||
Kd | 7.72 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IC50 | 7.63 | None, (2015) None:None:None | ||||
FLT3
Receptor-type tyrosine-protein kinase FLT3
10 Activities
Items per page:
1 – 10 of 10
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 9.43 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 9.27 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 9.19 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 9.17 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 9.15 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 9.15 | J. Med. Chem., (2013) 56:20:8032 | ||||
Kd | 8.82 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.36 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
EC50 | 8 | J. Med. Chem., (2014) 57:9:3856 | ||||
Kd | 7.75 | Science, (2017) 358:6367:None | ||||
RET
Proto-oncogene tyrosine-protein kinase receptor Ret
7 Activities
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1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.3 | |||||
Kd | 8.66 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.51 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.39 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.39 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IC50 | 8.3 | J. Med. Chem., (2012) 55:8:3614 | ||||
Ki | 7.9 | None, None:None:None | ||||
KIT
Mast/stem cell growth factor receptor Kit
7 Activities
Items per page:
1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.6 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.46 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.25 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.24 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.19 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.17 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.96 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
JAK2
Tyrosine-protein kinase JAK2
3 Activities
MAP3K11
Mitogen-activated protein kinase kinase kinase 11
3 Activities
BLK
Tyrosine-protein kinase Blk
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.2 | None, None:None:None | ||||
Kd | 7.6 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
FLT1
Vascular endothelial growth factor receptor 1
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.8 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Ki | 7.6 | None, None:None:None | ||||
SRC
Proto-oncogene tyrosine-protein kinase Src
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.2 | None, None:None:None | ||||
Kd | 8.08 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
KDR
Vascular endothelial growth factor receptor 2
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8 | None, (2015) None:None:None | ||||
Ki | 7.7 | None, None:None:None | ||||
LYN
Tyrosine-protein kinase Lyn
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.9 | None, None:None:None | ||||
Kd | 7.58 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IRAK1
Interleukin-1 receptor-associated kinase 1
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.01 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Ki | 8 | None, None:None:None | ||||
ROS1
Proto-oncogene tyrosine-protein kinase ROS
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.2 | None, None:None:None | ||||
Kd | 7.54 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
MAP3K10
Mitogen-activated protein kinase kinase kinase 10
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.42 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Ki | 8.4 | None, None:None:None | ||||
PLK4
Serine/threonine-protein kinase PLK4
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.38 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Ki | 8 | None, None:None:None | ||||
MAPK8
Mitogen-activated protein kinase 8
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
EC50 | 8 | J. Med. Chem., (2012) 55:8:3614 | ||||
DAPK3
Death-associated protein kinase 3
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.89 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
PDPK1
3-phosphoinositide-dependent protein kinase 1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.1 | None, None:None:None | ||||
FYN
Tyrosine-protein kinase Fyn
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.55 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
PDGFRB
Platelet-derived growth factor receptor beta
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.48 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
FLT4
Vascular endothelial growth factor receptor 3
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.04 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
MAPK10
Mitogen-activated protein kinase 10
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8 | None, None:None:None | ||||
FGFR3
Fibroblast growth factor receptor 3
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.8 | None, None:None:None | ||||
ZAP70
Tyrosine-protein kinase ZAP-70
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.68 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
JAK1
Tyrosine-protein kinase JAK1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.68 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
STK16
Serine/threonine-protein kinase 16
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.77 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IKBKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.89 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
TYK2
Non-receptor tyrosine-protein kinase TYK2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.8 | None, None:None:None | ||||
STK17B
Serine/threonine-protein kinase 17B
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.04 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
FER
Tyrosine-protein kinase Fer
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.9 | None, None:None:None | ||||
CSNK2A2
Casein kinase II subunit alpha'
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.85 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
MAPK9
Mitogen-activated protein kinase 9
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
EC50 | 8 | J. Med. Chem., (2012) 55:8:3614 | ||||
SLK
STE20-like serine/threonine-protein kinase
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.6 | None, None:None:None | ||||
FRK
Tyrosine-protein kinase FRK
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.9 | None, None:None:None | ||||
NEK6
Serine/threonine-protein kinase Nek6
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.2 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
NEK7
Serine/threonine-protein kinase Nek7
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.96 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
PLK3
Serine/threonine-protein kinase PLK3
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.29 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
NEK5
Serine/threonine-protein kinase Nek5
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.89 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
ULK3
Serine/threonine-protein kinase ULK3
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.15 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IRAK3
Interleukin-1 receptor-associated kinase 3
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.96 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
NEK9
Serine/threonine-protein kinase Nek9
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.8 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
DDR1
Epithelial discoidin domain-containing receptor 1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.03 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
TNK1
Non-receptor tyrosine-protein kinase TNK1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.6 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
EIF2AK4
eIF-2-alpha kinase GCN2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.48 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
TBK1
Serine/threonine-protein kinase TBK1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.64 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
ULK2
Serine/threonine-protein kinase ULK2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.72 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
PTK2B
Protein-tyrosine kinase 2-beta
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.54 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.57 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
SIK2
Serine/threonine-protein kinase SIK2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.6 | None, None:None:None | ||||
ULK1
Serine/threonine-protein kinase ULK1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.85 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
MAP3K9
Mitogen-activated protein kinase kinase kinase 9
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.37 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
MYH10
Myosin-10
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|---|---|---|---|
Kd | 6.64 | Science, (2017) 358:6367:None | ||