Pharos : Ligand Details

Target Activities

SYK

Tclin

Tyrosine-protein kinase SYK

9 Activities

Items per page:

1 – 9 of 9

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.63	None, (2015) None:None:None

Kd	7.72	Nat. Biotechnol., (2011) 29:11:1046	22037378

EC50	8	J. Med. Chem., (2012) 55:8:3614	22257213

EC50	8	J. Med. Chem., (2012) 55:8:3614	22257213

EC50	8	J. Med. Chem., (2012) 55:8:3614	22257213

EC50	8	J. Med. Chem., (2012) 55:8:3614	22257213

IC50	8.26	None, (2015) None:None:None

Kd	7.71999979		22037378

IC50	7.76999998		23151054

FLT3

Tclin

Receptor-type tyrosine-protein kinase FLT3

9 Activities

Items per page:

1 – 9 of 9

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
EC50	8	J. Med. Chem., (2014) 57:9:3856	24779514

Kd	8.36	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.82	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.15	J. Med. Chem., (2013) 56:20:8032	24044867

Kd	9.15	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.17	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.19	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.27	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.43	Nat. Biotechnol., (2011) 29:11:1046	22037378

KIT

Tclin

Mast/stem cell growth factor receptor Kit

7 Activities

Items per page:

1 – 7 of 7

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.96	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.17	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.19	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.24	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.25	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.46	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.6	Nat. Biotechnol., (2011) 29:11:1046	22037378

RET

Tclin

Proto-oncogene tyrosine-protein kinase receptor Ret

6 Activities

Items per page:

1 – 6 of 6

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.3	J. Med. Chem., (2012) 55:8:3614	22257213

Kd	8.39	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.39	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.51	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.66	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	8.30000019		19107952

JAK2

Tclin

Tyrosine-protein kinase JAK2

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
EC50	7.89	J. Med. Chem., (2014) 57:9:3856	24779514

IC50	8.22	Bioorg. Med. Chem. Lett., (2014) 24:10:2278	24726806

Kd	8.46	Nat. Biotechnol., (2011) 29:11:1046	22037378

MAP3K11

Tchem

Mitogen-activated protein kinase kinase kinase 11

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.96	J. Med. Chem., (2013) 56:20:8032	24044867

Kd	7.96	Nat. Biotechnol., (2011) 29:11:1046	22037378

TBK1

Tchem

Serine/threonine-protein kinase TBK1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.64		Nat. Biotechnol., (2011) 29:11:1046	22037378

ROS1

Tclin

Proto-oncogene tyrosine-protein kinase ROS

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.54		Nat. Biotechnol., (2011) 29:11:1046	22037378

EIF2AK4

Tchem

eIF-2-alpha kinase GCN2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.48		Nat. Biotechnol., (2011) 29:11:1046	22037378

FYN

Tclin

Tyrosine-protein kinase Fyn

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.55		Nat. Biotechnol., (2011) 29:11:1046	22037378

NEK5

Tchem

Serine/threonine-protein kinase Nek5

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.89		Nat. Biotechnol., (2011) 29:11:1046	22037378

DDR1

Tchem

Epithelial discoidin domain-containing receptor 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.03		Nat. Biotechnol., (2011) 29:11:1046	22037378

IKBKE

Tchem

Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.89		Nat. Biotechnol., (2011) 29:11:1046	22037378

STK16

Tchem

Serine/threonine-protein kinase 16

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.77		Nat. Biotechnol., (2011) 29:11:1046	22037378

NEK9

Tchem

Serine/threonine-protein kinase Nek9

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.8		Nat. Biotechnol., (2011) 29:11:1046	22037378

MAP3K9

Tchem

Mitogen-activated protein kinase kinase kinase 9

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.37		Nat. Biotechnol., (2011) 29:11:1046	22037378

IRAK1

Tchem

Interleukin-1 receptor-associated kinase 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.01		Nat. Biotechnol., (2011) 29:11:1046	22037378

ULK2

Tchem

Serine/threonine-protein kinase ULK2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.72		Nat. Biotechnol., (2011) 29:11:1046	22037378

PLK4

Tchem

Serine/threonine-protein kinase PLK4

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.38		Nat. Biotechnol., (2011) 29:11:1046	22037378

MAPK9

Tchem

Mitogen-activated protein kinase 9

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	8		J. Med. Chem., (2012) 55:8:3614	22257213

MAPK8

Tchem

Mitogen-activated protein kinase 8

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)