CHEMBL4462318
Ligand Summary
Name: 2,6-difluoro-N-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinolin-4-yloxy)phenyl)benzenesulfonamide
PubChem: 67073846
ChEMBL: CHEMBL4462318
LyCHI: NS7DRFCS4ZKB
Target Activities
EGFR
Epidermal growth factor receptor
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Kd | 7.8 | J Med Chem, (2018) 61:14:6277 | ||||
LYN
Tyrosine-protein kinase Lyn
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Kd | 7.96 | J Med Chem, (2018) 61:14:6277 | ||||
MET
Hepatocyte growth factor receptor
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Kd | 8.22 | J Med Chem, (2018) 61:14:6277 | ||||
ABL2
Tyrosine-protein kinase ABL2
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Kd | 7.8 | J Med Chem, (2018) 61:14:6277 | ||||
MAP4K5
Mitogen-activated protein kinase kinase kinase kinase 5
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Kd | 8.1 | J Med Chem, (2018) 61:14:6277 | ||||
AXL
Tyrosine-protein kinase receptor UFO
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Kd | 8.22 | J Med Chem, (2018) 61:14:6277 | ||||
RIPK2
Receptor-interacting serine/threonine-protein kinase 2
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Kd | 7.77 | J Med Chem, (2018) 61:14:6277 | ||||
TNK1
Non-receptor tyrosine-protein kinase TNK1
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 7.85 | J Med Chem, (2018) 61:14:6277 | ||||