Pharos : Ligand Details - NPKH9YCZS449

You are using an outdated browser. Please upgrade your browser to improve your experience.

Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

Name: nordihydroguiaretic acid

PubChem: 4534

ChEMBL: CHEMBL52

LyCHI: NPKH9YCZS449

Target Activities

ALOX5

Tclin

Arachidonate 5-lipoxygenase

9 Activities

Items per page:

1 – 9 of 9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.6		Bioorg. Med. Chem., (2011) 19:21:6316	21958737

IC50	7.07		J. Med. Chem., (1989) 32:6:1190	2542553

IC50	7		Eur J Med Chem, (2018) 156:None:534	30025348

IC50	6.96		J. Nat. Prod., (2009) 72:10:1857	19848434

IC50	6.92		Bioorg. Med. Chem., (2011) 19:21:6340	21958738

IC50	6.89		J. Nat. Prod., (2007) 70:5:859	17378609

IC50	6.8		J. Med. Chem., (1990) 33:4:1186	2157009

IC50	6.42		Bioorg. Med. Chem., (2008) 16:24:10332	18976930

IC50	6.3		J. Nat. Prod., (1998) 61:3:347	9544564

ALOX15

Tchem

Arachidonate 15-lipoxygenase

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.96		J. Med. Chem., (2002) 45:12:2659	12036375

IC50	6.96		J. Nat. Prod., (2003) 66:2:230	12608855

IC50	6.96		J. Med. Chem., (2014) 57:10:4035	24684213

IC50	6.6		Bioorg. Med. Chem., (2007) 15:23:7408	17869117

ALOX12

Tchem

Arachidonate 12-lipoxygenase, 12S-type

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.96		J. Med. Chem., (2011) 54:15:5485	21739938

IC50	6.75		J. Nat. Prod., (2003) 66:2:230	12608855

CYP19A1

Tclin

Aromatase

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.96		Bioorg. Med. Chem. Lett., (2010) 20:10:3050	20413308

HSD17B2

Tchem

Estradiol 17-beta-dehydrogenase 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.42		J Nat Prod, (2017) 80:4:965	28319389

LTB4R

Tchem

Leukotriene B4 receptor 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.07		J. Med. Chem., (1992) 35:7:1299	1313879

TRPA1

Tclin

Transient receptor potential cation channel subfamily A member 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	5.31		Eur J Med Chem, (2019) 170:None:141	30878828